Publications by authors named "S Chernausek"
Aims: In the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study, an intervention trial followed by an observational phase, half the participants reached the primary outcome [hemoglobin A1c (HbA1c) ≥ 8% for at least 6 months] within 4 years, which was associated with a decrease in C-peptide oral disposition index (oDI). We aimed to identify circulating microRNA (miRNA) species associated with a decline in beta cell function.
Methods: Following a preliminary survey of select participants using nCounter Human v3 miRNA Panel (NanoString Technologies), polymerase chain reaction analyses were carried out for 17 miRNAs from 365 participants from samples at baseline, 24, 60, 96, and 120 months.
Article Synopsis
- Genome-wide polygenic risk scores (PRS) are effective in predicting type 2 diabetes (T2D) risk, particularly in Europeans, but their utility in non-European populations, such as Asian Indians, is less understood.
- The study analyzed PRS models using data from 13,974 Asian Indian individuals, comparing their predictive power against European-derived PRS models and found significant efficacy in identifying T2D risk.
- Results indicated that the Asian Indian PRS outperformed the European PRS in predicting risk, highlighting the importance of including diverse ethnic groups in genetic and clinical research for more accurate risk assessment.
Motivation: statistics from genome-wide association studies enable many valuable downstream analyses that are more efficient than individual-level data analysis while also reducing privacy concerns. As growing sample sizes enable better-powered analysis of gene-environment interactions, there is a need for gene-environment interaction-specific methods that manipulate and use summary statistics.
Results: We introduce two tools to facilitate such analysis, with a focus on statistical models containing multiple gene-exposure and/or gene-covariate interaction terms.
Impact of youth onset type 2 diabetes during pregnancy on microvascular and cardiac outcomes.
Diabetes Res Clin Pract
September 2023
Aims: To examine the impact of pregnancy on microvascular and cardiovascular measures in women with youth-onset T2D.
Methods: Microvascular and cardiovascular measures were compared in in a cohort of 116 women who experienced a pregnancy of ≥ 20 weeks gestation and 291 women who did not among women in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study.
Results: Cox regression models adjusted for participant characteristics at baseline including age, race/ethnicity, household income, diabetes duration, HbA1c (>6%), and BMI, demonstrated those who experienced pregnancy had 2.
Article Synopsis
- An International Consensus Guideline was established by pediatric endocrine experts from 10 societies, summarizing findings from discussions based on 1300 articles regarding short stature after being born small for gestational age (SGA).
- The guideline highlights new insights into the causes of short stature, potential long-term health impacts, and recommends treatment options that include both growth hormone and gonadotropin-releasing hormone agonist for specific cases.
- Accurate diagnosis of SGA is emphasized through careful measurement and growth chart use, alongside the need for early life follow-up, neurodevelopment assessments, and lifestyle counseling for young adults to address health risks linked to SGA.