Publications by authors named "S Chemmalar"

Article Synopsis
  • Breast cancer is the most common cancer among women, causing nearly 685,000 deaths in 2020, with epidermal growth factor receptors (EGFRs) linked to its development and treatment resistance.
  • EGFR has four homologues, and while gefitinib (GEF), a tyrosine kinase inhibitor for EGFR1, shows promise in treating breast cancer, clinical trials have not met expectations, highlighting a gap in understanding EGFR signaling.
  • Ongoing research into molecular pathways and the use of nanomedicines synthesized with GEF is crucial for improving treatment outcomes against breast cancer.
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The meat is a novel concept in food biotechnology comprising field of tissue engineering and cellular agriculture. It involves production of edible biomass by culture of stem cells harvested from the muscle of live animals by self-organizing or scaffolding methodology. It is considered as efficient, environmental friendly, better ensuring public safety and nutritional security, as well as ethical way of producing meat.

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Calcium carbonate has slowly paved its way into the field of nanomaterial research due to its inherent properties: biocompatibility, pH-sensitivity, and slow biodegradability. In our efforts to synthesize calcium carbonate nanoparticles (CSCaCONP) from blood cockle shells (), we developed a simple method to synthesize CSCaCONP, and loaded them with gefitinib (GEF) and paclitaxel (PTXL) to produce mono drug-loaded GEF-CSCaCONP, PTXL-CSCaCONP, and dual drug-loaded GEF-PTXL-CSCaCONP without usage of toxic chemicals. Fourier-transform infrared spectroscopy (FTIR) results reveal that the drugs are bound to CSCaCONP.

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