SUSPECTED ENVIRONMENTAL AND SOCIO-ECONOMIC CAUSES OF DIABETES MELLITUS AND ASSOCIATED OCULAR COMPLICATIONS IN THE SUMY REGION, UKRAINE, FOR THE PERIOD OF 2011-2016.

The aim of the study was to compare and research: the general prevalence of DM in the Sumy region compared with the prevalence of DM in the whole of Ukraine during the years 2011-2016; the prevalence of ocular complications of diabetes and their tendency to progress in Ukraine and Sumy region over this period; various demographical traits of the prevalence of ocular complications of diabetes and the dependence of prevalence of ocular complications of diabetes upon environmental causes and various socio-economic factors. We conducted a statistical analysis of data on diabetes and its complications in the whole of Ukraine and the Sumy region. The materials that were analyzed were collected over the last 6 years from the Department of Endocrine diseases of the Regional Hospital of Sumy.

Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.

Carboxypeptidase E (CPE) is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. One of the features of type 2 diabetes mellitus (T2DM) is an elevation in the proinsulin level and/or proinsulin/insulin molar ratio, suggesting that mutations in proinsulin processing enzymes may contribute to the development of T2DM. We scanned CPE for mutations in a collection of Ashkenazi T2DM families and identified five novel single nucleotide polymorphisms (SNPs).

A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population.

A total of 896 individuals of Ashkenazi Jewish descent were ascertained in Israel from 267 multiplex families, including 472 sib-pairs affected with type 2 diabetes. A genome-wide scan with average marker spacing of 9.5 cM revealed five regions on four chromosomes (4q, 8q, 14q, and 20q) that exhibited nominal evidence for linkage (P < 0.