Publications by authors named "S Charriere"
Background And Objective: Adult patients with early-treated phenylketonuria (AwET-PKU) may present some subtle neurocognitive deficits. The aim of the study was to investigate 1) neurocognitive functions in a large group of AwET-PKU 2) the influence of plasma phenylalanine (Phe).
Methods: Participants: 187 AwET-PKU (classic PKU [cPKU] 81%, mild PKU [mPKU] 14%, and mild persistent hyperphenylalaninemia [MPH] 5%).
Article Synopsis
- Phenylketonuria (PKU) is a serious genetic disorder that can lead to severe cognitive impairment and other health issues if untreated, prompting a study on its economic impact in France.
- A retrospective analysis was conducted using health insurance claims from the national database, identifying 3549 PKU patients and comparing their healthcare costs with matched controls in 2018.
- Results revealed that PKU patients incurred healthcare costs that were 7.7 times higher than those of non-PKU controls, mainly due to expensive pharmaceutical needs like dietary amino acid supplements, particularly impacting those diagnosed early.
Background: Determining the cause of hypoglycemia partly relies on blood insulin and C-peptide assays. Although the pancreatic secretion of these peptides is equimolar, discrepancies in their concentrations may occur.
Case Presentation: We report the case of a 73-year-old woman with type 2 diabetes mellitus (T2DM) and a history of gastric bypass.
Article Synopsis
- - The study focuses on dysbetalipoproteinemia (DBL), a lipid disorder linked to cardiovascular disease risk, especially in individuals with the ε2ε2 genotype, and evaluates the effectiveness of nine different screening algorithms, including a new one developed by the researchers.
- - Patients were classified into three groups based on their genetic background and the diagnostic performance of the algorithms was assessed against a gold standard of specific triglyceride levels and genotypes.
- - The findings indicate that the "Hospices Civils de Lyon (HCL) algorithm" demonstrated superior diagnostic ability for detecting DBL in both ε2ε2 and rare variant carriers compared to other algorithms, highlighting the need for further investigation into the accuracy of these screening methods.
Background: Influenza vaccines are effective in decreasing hospitalizations and mortality related to influenza and its complications. However, the Vaccine Coverage Rate of influenza remains low and multifaceted efforts are required to improve it. The aim of this study was to assess the impact on influenza vaccine perception using a digital tool among outpatients and health care workers (HCWs).
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