Publications by authors named "S Chappell"
Article Synopsis
- The EuroHeart project aims to establish standardized definitions for outcome measures in cardiovascular clinical studies to enhance the evaluation of medical interventions and care.
- A group of 82 experts formed five Working Groups to identify key outcome measures for various cardiovascular conditions, using a systematic review and consensus methods to define these measures.
- In total, 24 mandatory (Level 1) and 48 optional (Level 2) outcome measures were established across five cardiovascular disease areas, providing a foundation for improved research and patient care quality.
The organophosphate (OP)-hydrolyzing enzyme phosphotriesterase (PTE, variant L7ep-3a) immobilized within a partially oxidized mesoporous silicon nanoparticle cage is synthesized and the catalytic performance of the enzyme@nanoparticle construct for hydrolysis of a simulant, dimethyl p-nitrophenyl phosphate (DMNP), and the live nerve agent VX is benchmarked against the free enzyme. In a neutral aqueous buffer, the optimized construct shows a ≈2-fold increase in the rate of DMNP turnover relative to the free enzyme. Enzyme@nanoparticles with more hydrophobic surface chemistry in the interior of the pores show lower catalytic activity, suggesting the importance of hydration of the pore interior on performance.
View Article and Find Full Text PDFArticle Synopsis
- * A working group, including experts from the European Society of Cardiology, conducted a systematic review and reached consensus on mandatory (Level 1) and optional (Level 2) measures through a Delphi process.
- * The final catalogue includes five Level 1 and two Level 2 outcome measures, along with five additional monitoring outcomes, which will enhance research quality and improve heart failure care.
Article Synopsis
- The study investigates the genetic variations in the SR-BI gene, which plays a role in hepatitis C virus (HCV) entry into cells, by analyzing six specific single nucleotide polymorphisms (SNPs) in individuals with a history of HCV infection.
- Findings reveal that the rs5888 variant allele T is more common in individuals with advanced liver fibrosis and relates to lower SR-BI mRNA levels in liver tissue samples.
- The research suggests that the rs5888 variant may serve as a genetic marker to identify patients at higher risk for severe disease due to its link to decreased SR-BI expression and increased fibrosis progression.