Publications by authors named "S Chandramathi"
[This corrects the article DOI: 10.1371/journal.pgph.
View Article and Find Full Text PDFThe decline in dengue incidence and/or prevalence during the COVID-19 pandemic (2020-22) appears to be attributed to reduced treatment-seeking rates, under-reporting, misdiagnosis, disrupted health services and reduced exposure to mosquito vectors due to prevailing lockdowns. There is limited scientific data on dengue virus (DENV) disease during the COVID-19 pandemic. Here, we conducted a community-based, cross-sectional, cluster-randomized survey to assess anti-DENV and anti-SARS-CoV-2 seroprevalence, and also estimated the spatial distribution of DENV-positive aedine mosquito vectors during the COVID-19 pandemic across all the 38 districts of Tamil Nadu, India.
View Article and Find Full Text PDFBackground: Dengue is a vector-borne viral disease impacting millions across the globe. Nevertheless, akin to many other diseases, reports indicated a decline in dengue incidence and seroprevalence during the COVID-19 pandemic (2020-22). This presumably could be attributed to reduced treatment-seeking rates, under-reporting, misdiagnosis, disrupted health services and reduced exposure to vectors due to lockdowns.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated the role and mutations of the XBB omicron variant in COVID-19 cases among hospitalized patients in Tamil Nadu, India, particularly in the context of increased breakthrough infections despite vaccination efforts.
- - Researchers analyzed nasopharyngeal and oropharyngeal swabs from 98 patients using real-time PCR and Next Generation Sequencing, identifying 43 mutations in the S gene, including two new mutations, A27S and T747I, which had not been previously reported.
- - The findings suggested that factors such as age and underlying health conditions were more critical in susceptibility to infection than vaccination status, with XBB.3 being the main variant identified among vaccinated individuals experiencing breakthrough infections.
Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. The study investigates whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. The plasma cytokines were measured using a commercial Bio-Plex Pro Human Cytokine 17-plex assay.
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