A New Analytical Method for Quantifying Acid-End-Cap PLGA in Sub-Milligram Quantities.

Characterization of PLGA polymers used in FDA-approved drug products is critical for quality control and qualitative/quantitative (Q1/Q2) evaluation of potential generic formulations. Various techniques have been developed and used to characterize the molecular properties of PLGA polymers, such as molecular weight, molecular composition, and molecular structure. Commonly used techniques include gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), semisolvent methods, and GPC-based intrinsic viscosity measurement.

When connecting with LGBTQ+ communities helps and why it does: A meta-analysis of the relationship between connectedness and health-related outcomes.

We conducted a multilevel meta-analysis of 390 effect sizes from 167 studies with 157,923 participants examining the relationship between connectedness with lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ+) communities and health-related outcomes, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We conducted our initial search in January 2023 in APA PsycInfo, ERIC, Medline, and Open Dissertations, selecting studies that (a) measured LGBTQ+ community connectedness, (b) measured health, and (c) provided an estimate of the relationship between LGBTQ+ community connectedness and health. We found that connectedness with LGBTQ+ communities promotes mental health (r = .

Understanding How Coming Out Goes Well for Sexual and Gender Minorities.

Coming out is often seen as a positive event that bolsters well-being for sexual and gender minorities (SGMs). However, the relationship between coming out and well-being is more complex among SGMs. We set out to evaluate the reliability and validity of two recent scales related to coming out: the Coming Out Vigilance and Positive Coming Out Responses scales.

Navigating faith transitions: A 4-year longitudinal examination of religious deidentification among LGBTQ+ latter-day saints.

Many lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ+) individuals raised in conservative religious traditions present to therapy with questions about how to navigate tension between their sexual/gender and religious identities. For therapists, having accurate information about (a) the typical process of religious deidentification, (b) its antecedents, and (c) its outcomes is critical to empowering these clients to make the decisions that are best for them. We present data from a preregistered 4-year longitudinal study of 164 LGBTQ+ people who were active members of the Church of Jesus Christ of Latter-day Saints (CJCLDS) at baseline to examine the phenomenology, antecedents, and outcomes of religious change.

A Resident-Led Quality Improvement Project in a Community Based Hospital Emergency Department - The Benefits of Simplified Plan-Do-Study-Act/Patient-Safety Quality Improvement Projects Regardless of Staffing Levels.

Introduction: An emergency department (ED) resident believed ED patients, who needed a simple laceration repair, would be better served if the ED used a laceration cart for supplies, as opposed to the hunt-and-gather method for collecting needed supplies. To address this issue, a two-step Plan-Do-Study-Act/Patient-Safety quality improvement (PDSA/PS QI) project was initiated, with the intent that the project could be completed in a timely manner regardless of staffing levels. The primary purpose of the project was two-fold: 1) to explore the possible time-to-repair benefits of using a laceration repair supply cart in the emergency department and 2) to determine the feasibility of conducting a simple multi-cycle PDSA/PS QI project in a potential staffing-shortage environment.