Subclinical epileptiform activity in the Alzheimer continuum: association with disease, cognition and detection method.

Background: Epileptic seizures are an established comorbidity of Alzheimer's disease (AD). Subclinical epileptiform activity (SEA) as detected by 24-h electroencephalography (EEG) or magneto-encephalography (MEG) has been reported in temporal regions of clinically diagnosed AD patients. Although epileptic activity in AD probably arises in the mesial temporal lobe, electrical activity within this region might not propagate to EEG scalp electrodes and could remain undetected by standard EEG.

18F-Florbetapir PET in Primary Cerebral Amyloidoma.

Amyloid deposition can lead to Alzheimer disease and cerebral amyloid angiopathy. Rarely, it presents as a solitary focal deposition, primary cerebral amyloidoma, which can be misinterpreted as a neoplasm because of the "tumor-like" appearances. We present the case of a 54-year-old woman where MRI revealed a T2-hyperintense mass periventricular in the white matter with moderate contrast enhancement.

F-FDG PET, the early phases and the delivery rate of F-AV45 PET as proxies of cerebral blood flow in Alzheimer's disease: Validation against O-HO PET.

Introduction: Dual-biomarker positron emission tomography (PET), providing complementary information on cerebral blood flow and amyloid-β deposition, is of clinical interest for Alzheimer's disease (AD). The purpose of this study was to validate the perfusion components of early-phase F-florbetapir (eAV45), the F-AV45 delivery rate (R1), and F-FDG against O-HO PET and assess how they change with disease severity.

Methods: This study included ten controls, 19 amnestic mild cognitive impairment, and 10 AD dementia subjects.