Publications by authors named "S Cerps"
Background: Respiratory virus infections are main triggers of asthma exacerbations. Tezepelumab, an anti-TSLP mAb, reduces exacerbations in patients with asthma, but the effect of blocking TSLP on host epithelial resistance and tolerance to virus infection is not known.
Aim: To examine effects of blocking TSLP in patients with asthma on host resistance (IFNβ, IFNλ, and viral load) and on the airway epithelial inflammatory response to viral challenge.
Background: Lower respiratory infections caused by ssRNA viruses are a major health burden globally. Translational mouse models are a valuable tool for medical research, including research on respiratory viral infections. In in vivo mouse models, synthetic dsRNA can be used as a surrogate for ssRNA virus replication.
View Article and Find Full Text PDFAllergic asthma is linked to impaired bronchial epithelial secretion of IFNs, which may be causally linked to the increased risk of viral exacerbations. We have previously shown that allergen immunotherapy (AIT) effectively reduces asthma exacerbations and prevents respiratory infections requiring antibiotics; however, whether AIT alters antiviral immunity is still unknown. To investigate the effect of house dust mite sublingual AIT (HDM-SLIT) on bronchial epithelial antiviral and inflammatory responses in patients with allergic asthma.
View Article and Find Full Text PDFArticle Synopsis
- LL-37 enhances the effects of synthetic double-stranded RNA (poly I:C) on toll-like receptor 3 (TLR3) expression and signaling in bronchial epithelial cells.
- The interaction between LL-37 and poly I:C leads to increased TLR3 mRNA and protein levels, which is linked to improved uptake of poly I:C.
- Dexamethasone reduces the LL-37/poly I:C-induced TLR3 expression by increasing IκBα protein levels, indicating it may inhibit NF-κB activity and downstream TLR3 signaling.
Article Synopsis
- The study investigates how exposure to house dust mite (HDM) affects the immune response of human bronchial epithelial cells (HBECs) in asthma patients when challenged with viral infections.
- Results showed that HBECs from HDM-sensitized patients exhibited reduced production of key anti-viral and anti-bacterial molecules following viral stimulation compared to unsensitized patients, indicating impaired immune responses.
- The findings suggest that HDM sensitization compromises the airway's defense mechanisms, potentially worsening asthma exacerbations and increasing susceptibility to infections.