Publications by authors named "S Cermelli"
SeptiCyte RAPID is a transcriptional host response assay that discriminates between sepsis and non-infectious systemic inflammation (SIRS) with a one-hour turnaround time. The overall performance of this test in a cohort of 419 patients has recently been described [Balk et al., J Clin Med 2024, 13, 1194].
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- SeptiCyte RAPID is a molecular test designed to differentiate between sepsis and non-infectious systemic inflammation, utilizing a blood RNA sample to deliver results in about one hour.
- A study tested both retrospective and prospective patient samples in ICU settings, with physicians evaluating cases without knowledge of the test outcomes.
- The test showed strong performance, especially under the Sepsis-2 criteria, with high AUC values and predictive capabilities, indicating it is a crucial tool for diagnosing sepsis, though some discrepancies were noted when compared to the Sepsis-3 criteria.
Objectives: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death and disability among children worldwide. Identifying sepsis in pediatric patients is difficult and can lead to treatment delay. Our objective was to assess the host proteomic response to infection utilizing an aptamer-based multiplexed proteomics approach to identify novel serum protein changes that might help distinguish between pediatric sepsis and infection-negative systemic inflammation and hence can potentially improve sensitivity and specificity of the diagnosis of sepsis over current clinical criteria approaches.
View Article and Find Full Text PDFRationale: A molecular test to distinguish between sepsis and systemic inflammation of noninfectious etiology could potentially have clinical utility.
Objectives: This study evaluated the diagnostic performance of a molecular host response assay (SeptiCyte LAB) designed to distinguish between sepsis and noninfectious systemic inflammation in critically ill adults.
Methods: The study employed a prospective, observational, noninterventional design and recruited a heterogeneous cohort of adult critical care patients from seven sites in the United States (n = 249).