Publications by authors named "S Cederholm"
Article Synopsis
- The study aimed to assess the long-term safety of anakinra for treating patients with systemic juvenile idiopathic arthritis (sJIA) using data from the Pharmachild registry.
- A total of 306 patients were analyzed, showing that while adverse events largely involved infections, the overall occurrence rate decreased over time, with most severe reactions occurring during the first six months of treatment.
- Despite a high discontinuation rate (76%) primarily due to treatment inefficacy or achieving remission, no deaths or cancers were reported, affirming the medication's safety in the long term.
Background: Adult deformity correction spine surgery can be associated with significant perioperative pain because of inflammatory, muscular, neuropathic, and postsurgical pain. α-2 Agonists have intrinsic antinociceptive and antihyperalgesic properties that can potentially reduce both postoperative opioid consumption and pain. We hypothesized that intraoperative dexmedetomidine would reduce postoperative opioid consumption and improve pain scores in deformity correction spine surgery.
View Article and Find Full Text PDFBackground: Pharmacovigilance signal detection largely relies on individual case reports, but longitudinal health data are being explored as complementary information sources. Research to date has focused on the ability of epidemiological methods to distinguish established adverse drug reactions (ADRs) from unrelated adverse events.
Objective: The aim of this study was to evaluate a process for structured clinical and epidemiological assessment of temporally associated drugs and medical events in electronic medical records.
A well-balanced human diet includes a significant intake of non-starch polysaccharides, collectively termed 'dietary fibre', from the cell walls of diverse fruits and vegetables. Owing to the paucity of alimentary enzymes encoded by the human genome, our ability to derive energy from dietary fibre depends on the saccharification and fermentation of complex carbohydrates by the massive microbial community residing in our distal gut. The xyloglucans (XyGs) are a ubiquitous family of highly branched plant cell wall polysaccharides whose mechanism(s) of degradation in the human gut and consequent importance in nutrition have been unclear.
View Article and Find Full Text PDFBackground: Foot compartment syndrome is diagnosed with intracompartmental pressure measurements. The purpose of this study was to determine the ability of two techniques to accurately place a needle tip within the medial foot compartment and to compare the proximity of the needle tip to the medial foot compartment neurovascular structures between the two techniques.
Materials And Methods: This was a laboratory study using ten unembalmed cadaveric ankle-foot specimens.