Publications by authors named "S Carmo"
This study introduces EpiAgePublic, a new method to estimate biological age using only three specific sites on the gene known for its connection to aging. Unlike traditional methods that require complex and extensive data, our model uses a simpler approach that is well-suited for next-generation sequencing technology, which is a more advanced method of analyzing DNA methylation. This new model overcomes some of the common challenges found in older methods, such as errors due to sample quality and processing variations.
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- The study investigates how the combination of amyloid beta and tau pathologies affects neurodegeneration in Alzheimer's disease using a new transgenic rat model (McGill-R-APPxhTau).
- Initial findings suggest that early exposure to both amyloid and phosphorylated tau can temporarily improve synaptic plasticity and cognitive functions, contrasting with the negative effects observed in models with only one of these pathologies.
- However, as the disease progresses, the combined presence of amyloid and tau leads to severe cognitive decline, increased neuroinflammation, and neuronal loss, indicating that the protective effects of tau are short-lived.
Eating behavior can be influenced by external factors; however, there is no consensus on the existence of differences in eating behavior between the sexes in stressful situations, such as the COVID-19 pandemic. This systematic review assessed whether there was a difference in eating behavior between sexes during the COVID-19 pandemic. A search of nine databases (Medline/Pubmed, Embase, Scielo, VHL, Scopus, PsycINFO, Web of Science, ProQuest, Google Scholar) was conducted in October 2023.
View Article and Find Full Text PDFBackground: Brain inflammation contributes significantly to the pathophysiology of Alzheimer's disease, and it is manifested by glial cell activation, increased production of cytokines/chemokines, and a shift in lipid mediators from a pro-homeostatic to a pro-inflammatory profile. However, whether the production of bioactive lipid mediators is affected at earlier stages, prior to the deposition of Aβ plaques and tau hyperphosphorylation, is unknown. The differential contribution of an evolving amyloid and tau pathology on the composition and abundance of membrane phospholipids and bioactive lipid mediators also remains unresolved.
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- Acute urinary retention in children is rare, often linked to urinary tract infections or obstructions.
- A 12-year-old girl experienced acute urinary retention, which was diagnosed as hematocolpos due to an obstructed hymen, confirmed by ultrasound.
- Treatment involved a hymen incision, and it's crucial to consider hematocolpos in young females without menstrual cycles who present with urinary retention symptoms.