Publications by authors named "S Caporuscio"
Article Synopsis
- Biological drugs have transformed severe asthma treatment, making remission an achievable goal, while the rise of autoimmune diseases suggests the need for combined therapies.
- A review of 26 retrospective studies analyzed real-life cases where asthmatic patients also received treatment for other immune-mediated inflammatory diseases (IMIDs) using monoclonal antibodies.
- The findings highlight the importance of these dual therapies in managing uncontrolled severe asthma, indicating a need for more research to evaluate their safety and effectiveness.
We previously examined the safety and immunogenicity of multiple vaccines administered to a military cohort, divided into two groups, the first composed of students at military schools, thus operating inside the national borders for at least 3 years, and the other formed of soldiers periodically engaged in a 9-month-long mission abroad (Lebanon). In the current study, we analyzed 112 individuals of this cohort, 50 pertaining to the first group and 62 to the second group, in order to examine the possible late appearance of side effects and to calculate the half-life of the induced antibodies. Moreover, the possible involvement of B-cell polyclonal activation as a pathogenetic mechanism for long term antibody persistence has even been explored.
View Article and Find Full Text PDFBullous pemphigoid (BP) is an autoimmune blistering skin disease, mainly observed in the elderly. Infections have been suggested as possible disease triggers. However, infections may even heavily influence the disease clinical course and mortality.
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- Military personnel receive various vaccines, but few studies explore their simultaneous effects, prompting a study on four specific vaccines in two Italian military cohorts.
- Among 180 participants, many had pre-existing antibodies to polio and unexpected levels for measles, mumps, and rubella before vaccination, while lower levels were identified for hepatitis A and influenza.
- After nine months, high protective antibody levels were seen for all vaccines, with notable results showing no interference between the vaccines and a strong immune response overall.
Chronic hepatitis B virus (HBV) infection may be reactivated by immunosuppressive drugs in patients with autoimmune inflammatory rheumatic diseases. This study evaluates HBV serum markers' prevalence in rheumatic outpatients belonging to Spondyloarthritis, Chronic Arthritis and Connective Tissue Disease diagnostic groups in Italy. The study enrolled 302 subjects, sex ratio (M/F) 0.
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