Publications by authors named "S Can"
Early markers of baked milk and egg tolerance in young children with IgE-mediated immediate reactions.
Eur Ann Allergy Clin Immunol
January 2025
Children with milk and egg allergies have outcomes in which, three-quarters are tolerant to baked forms of the allergenic food. Identifying predictors of tolerance to baked foods for IgE-mediated immediate-type reactions may guide the early introduction of baked allergens to diet and tolerance development. This study explores factors associated with early tolerance to baked foods.
View Article and Find Full Text PDFIntroduction: CHAPLE disease is a severe, ultra-rare disorder caused by CD55 gene mutations, leading to uncontrolled complement hyperactivation, protein-losing enteropathy, and systemic thrombosis. Recent advances in targeted therapies, particularly the C5 inhibitor pozelimab (Veopoz), offer new treatment options by addressing complement dysregulation, marking a shift from symptomatic to precision therapy.
Areas Covered: This review explores the pathophysiology, clinical manifestations, and current treatments for CHAPLE disease.
Article Synopsis
- STAT3 gain-of-function disease causes issues like immune system overactivity and growth problems, but long-term treatment with the JAK inhibitor ruxolitinib has shown promise in symptom relief.
- The study monitored clinical and immune responses of four patients over a year, noting significant changes in T cell populations and the normalization of blood cell profiles, which were previously dysregulated.
- Ruxolitinib treatment not only managed symptoms but also modified harmful immune cell characteristics and reduced certain auto-reactive T-cell clones, suggesting a potential pathway to better control the disease's impact.
This study examines the role of waste pickers in individual waste separation behavior. Given the environmental and economic importance of waste separation, this behavior has been extensively studied, but the influence of waste pickers-who perform waste separation as a livelihood, potentially substituting for the voluntary efforts expected from individuals-has been overlooked. Using stratified random sampling in İzmir, Turkey, we collected data from 670 individuals to test our hypotheses via the factor score regression method.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the visibility of the fetal optic chiasm and optic tracts through ultrasound and establish reference values for mid-trimester fetuses.
- It included 154 normal fetuses at 19-23 weeks of gestation, measuring various dimensions using a specific ultrasound technique, successfully visualizing OC and OTs in 70.8% of cases.
- Results showed that the dimensions of OC and OTs were positively correlated with measurements of the cavum septum pellucidum, as well as other growth indicators like biparietal diameter and head circumference.