Coconut Oil Mitigates the Effects of Aging on the Mongolian Gerbil Prostate.

Background: Benign prostatic hyperplasia (BPH) is a disease linked to the hormonal imbalance that occurs during aging and over the last decades, complementary and alternative medicines have come on the scene as a treatment option for BPH, such as herbal medicines. Coconut oil has been shown to be capable of interfering in testosterone-induced BPH. However, until now there is no study of the effect of coconut oil during aging.

Intraoperative nociceptive and clinical comparisons between ventral midline and flank ovariectomy in feral and stray cats.

Objectives: The aim of the present study was to evaluate the differences in intraoperative nociception, incision size and operative time between midline (OVE) and flank ovariectomy (OVE) in feral or stray cats.

Methods: Two groups of animals, the OVE group (n = 19) and the OVE group (n = 19), were evaluated at six intraoperative time points. Cats assigned to both groups were premedicated with dexmedetomidine (20 μg/kg IM) and methadone (0.

Midbrain dopamine drives splenic immunity through a brain-to-body circuit.

Midbrain dopamine neurons are well-known to shape central nervous system function, yet there is growing evidence for their influence on the peripheral immune systems. Here we demonstrate that midbrain dopamine neurons form a circuit to the spleen via a multisynaptic pathway from the dorsal vagal complex (DVC) through the celiac ganglion. Midbrain dopamine neurons modulate the activity of D1-like and D2-like dopamine receptor-expressing DVC neurons.

Factors Associated with Loss to Follow-Up in Pediatric Concussion Patients after Initial Visit: A Retrospective Study at a Concussion Clinic.

Objective: The objective of this retrospective study is to identify factors associated with loss to follow-up for postconcussion clearance in pediatric patients by comparing loss to follow-up and full clearance patients.

Study Design: This retrospective single-center cohort study analyzed 140 consecutive patients at a pediatric concussion clinic of a safety-net hospital for loss to follow-up, defined as not achieving clearance at last appointment. Univariate and multivariate regression models were fit on variables of interest, including demographic, mechanism and severity of concussion, and characteristics of the first evaluation postconcussion and follow-up management.

Early developmental effects of propofol exposure in different stages of zebrafish embryos.

The mechanism of action of propofol, a common intravenous anaesthetic, in early life stages is not well understood with contradictory studies showing neurotoxic and neurogenic effects in the developing brain. Zebrafish early life stages have been established as an alternative model for animal experimentation with propofol toxicological effects reported following chronic exposure. Yet, the acute exposure to other anaesthetics has been shown to induce early life stage-dependent toxicological outcomes.