Publications by authors named "S Camastra"
Purpose: Gestational obesity (GO) presents a multifaceted challenge to maternal and fetal health, with an escalating prevalence and far-reaching consequences extending beyond pregnancy. This perspective statement by the Italian Society of Obesity (SIO) provides current insights into the diagnosis, maternal and fetal impacts, and treatment strategies for managing this pressing condition.
Methods: This article provides a comprehensive review of the maternal and fetal effects of GO and provides suggestions on strategies for management.
Treatment with glucagon-like peptide 1 receptor agonists reduces liver steatosis and cardiometabolic risk (CMR). Few data are available on lipid metabolism, and no information is available on the postprandial lipidomic profile. Thus, we investigated how exenatide treatment changes lipid metabolism and composition during fasting and after a mixed-meal tolerance test (MMTT) in adults with severe obesity without diabetes.
View Article and Find Full Text PDFDifferential effects of bariatric surgery on plasma levels of ANGPTL3 and ANGPTL4.
Nutr Metab Cardiovasc Dis
November 2022
Article Synopsis
- Angiopoietin-like proteins ANGPTL3 and ANGPTL4 are key regulators of how the body stores and uses triglycerides, and they respond to changes after bariatric surgery (BS).
- In a study of 45 morbidly obese subjects undergoing two types of BS (RYGB and BPD), both surgeries led to significant weight loss and improved insulin sensitivity, but affected ANGPTL levels differently; ANGPTL4 decreased after both procedures while ANGPTL3 increased only after BPD.
- The results suggest that reduced ANGPTL4 is linked to fat loss and better blood sugar control, whereas the increase in ANGPTL3 after BPD is likely due to its malabsorptive effects,
Multiple beneficial cardiovascular effects of HDL depend on sphingosine-1-phosphate (S1P). S1P associates with HDL by binding to apolipoprotein M (ApoM). Insulin resistance is a major driver of dyslipidemia and cardiovascular risk.
View Article and Find Full Text PDFIt is well-established that adipose tissue accumulation is associated with insulin resistance through multiple mechanisms. One major metabolic link is the classical Randle cycle: enhanced release of free fatty acids (FFA) from hydrolysis of adipose tissue triglycerides impedes insulin-mediated glucose uptake in muscle tissues. Less well studied are the different routes of this communication.
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