Publications by authors named "S Calafato"
Objective: Psychoses affecting people with epilepsy increase disease burden and diminish quality of life. We characterized postictal psychosis, which comprises about one quarter of epilepsy-related psychoses, and has unknown causation.
Methods: We conducted a case-control cohort study including patients diagnosed with postictal psychosis, confirmed by psychiatric assessment, with available data regarding epilepsy, treatment, psychiatric history, psychosis profile, and outcomes.
Article Synopsis
- * A systematic review involved ten studies with nearly 19,000 participants, concluding that the burden of CNVs does not correlate with general cognitive performance.
- * However, specific schizophrenia-associated CNVs were linked to poorer verbal recall and perceptual reasoning abilities in individuals with psychotic disorders and their relatives, suggesting they may serve as biomarkers for cognitive impairment and increased disease risk.
Article Synopsis
- This study examines the relationships among various endophenotypes (cognitive, electrophysiological, and neuroanatomical traits) in psychosis through a large sample of 8,754 participants, including those with psychotic disorders, their relatives, and healthy controls.
- Significant associations were found among cognitive endophenotypes, while the P300 amplitude and latency were determined to be independent of each other, with P300 amplitude linked to specific cognitive functions like working memory.
- The results suggest that cognitive traits and their relationships are consistent across different groups, supporting the idea that psychosis risk exists on a continuum within the general population.
A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.
Am J Med Genet B Neuropsychiatr Genet
January 2018
This large multi-center study investigates the relationships between genetic risk for schizophrenia and bipolar disorder, and multi-modal endophenotypes for psychosis. The sample included 4,242 individuals; 1,087 patients with psychosis, 822 unaffected first-degree relatives of patients, and 2,333 controls. Endophenotypes included the P300 event-related potential (N = 515), lateral ventricular volume (N = 798), and the cognitive measures block design (N = 3,089), digit span (N = 1,437), and the Ray Auditory Verbal Learning Task (N = 2,406).
View Article and Find Full Text PDFThe "dysconnection hypothesis" of psychosis suggests that a disruption of functional integration underlies cognitive deficits and clinical symptoms. Impairments in the P300 potential are well documented in psychosis. Intrinsic (self-)connectivity in a frontoparietal cortical hierarchy during a P300 experiment was investigated.
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