Publications by authors named "S Cagnin"
SerpinB3, a member of the serine-protease inhibitor family, has emerged as a crucial player in various physiological and pathological processes. Initially identified as an oncogenic factor in squamous cell carcinomas, SerpinB3's intricate involvement extends from fibrosis progression and cancer to cell protection in acute oxidative stress conditions. This review explores the multifaceted roles of SerpinB3, focusing on its implications in fibrosis, metabolic syndrome, carcinogenesis and immune system impairment.
View Article and Find Full Text PDFMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a demanding medical condition for patients and society. It has raised much more public awareness after the COVID-19 pandemic since ME/CFS and long-COVID patients share many clinical symptoms such as debilitating chronic fatigue. However, unlike long COVID, the etiopathology of ME/CFS remains a mystery despite several decades' research.
View Article and Find Full Text PDFChronic liver disease (CLD) is a leading global cause of mortality, morbidity, and healthcare resource utilization. However, the burden of CLD is underestimated because the course of the disease is often asymptomatic until clinical decompensation and the development of life-threatening complications. In this study, we assessed the use of available blood tests from electronic medical records for identifying individuals with undiagnosed CLD in the general population.
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- Amyotrophic lateral sclerosis (ALS) is a serious motor neuron disease that leads to muscle wasting, paralysis, and death, and its causes involve complex mechanisms in various cell types, not just motor neurons.
- Researchers studied myocytes from a specific ALS mouse model and found that these muscle cells had impaired myogenic (muscle-building) capabilities compared to normal control cells.
- The study indicates that healthy myocytes can release factors that help restore the myogenic function in ALS-affected cells and identifies changes in secreted molecules like amino acids and lipids, highlighting the importance of skeletal muscle in ALS research.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, and the GALAD score is a diagnostic tool created to identify HCC in at-risk patients based on specific biomarkers.
- Analysis of 212 patients showed that those with HCC had higher GALAD scores compared to those with just cirrhosis, and higher scores were linked to lower survival rates.
- The study indicates that the GALAD score could serve as a valuable prognostic tool, potentially enhancing the management and treatment options for patients with HCC.