Rough endoplasmic reticulum expansion: a consistent finding in a patient cohort with vascular Ehlers-Danlos Syndrome and Osteogenesis Imperfecta.

Vascular Ehlers-Danlos Syndrome (vEDS) and Osteogenesis Imperfecta (OI) are two forms of connective tissue disorders. Previously, transmission electron microscopy of skin biopsies was routinely performed on all patients who were clinically suspected to have vEDS. At present, molecular genetics using genomic DNA extracted from a blood sample is the first line investigation for these patients.

High bone mass phenotype in a cohort of patients with Osteogenesis Imperfecta caused due to and C-propeptide cleavage variants in .

Objectives: Osteogenesis Imperfecta (OI) is a heterogeneous condition mainly characterised by bone fragility; extra-skeletal features in OI include blue sclerae, dentinogenesis imperfecta, skin laxity and joint hyper-extensibility. Most patients with OI are thought to have a low bone mass but contrary to expectations there are certain forms of OI with high bone mass which this study explores in further detail.

Method: A cohort of n = 6 individuals with pathogenic variants in and the C-propeptide cleavage variants in were included in this study.

Effect of hypnosis on masseter EMG recorded during the 'resting' and a slightly open jaw posture.

The aim of this experimental study was to determine whether minimal levels of electromyographic activity in the masseter muscle are altered when individuals are in a verified hypnotic state. Experiments were performed on 17 volunteer subjects (8 male, 9 female) all of whom gave informed consent. The subjects were dentate and had no symptoms of pain or masticatory dysfunction.

Selective stimulation of human tooth-pulp with a new stable method: responses and validation.

Introduction: The aims of this study were to establish a safe technique for selective stimulation of nerves in human tooth-pulp during long experiments and to validate its use even with stimuli of high intensities.

Methods: A custom-made veneer containing 2 silver wire-conductive cream electrodes was attached with cement to the labial surface of an upper central incisor tooth. A variety of stimulus intensities were applied, and sensory and reflex responses from jaw-closing muscles were recorded.

Forces, movements and reflexes produced by pushing human teeth.

Pushing a tooth results in movement of the tooth and reflex inhibition of activity in jaw-closing muscles. The aims of this study were to determine how much tooth movement is required to elicit such reflexes and whether this is dependent on the point of force application to the tooth. Eight experiments were performed on six volunteer subjects.