Publications by authors named "S Caccio"
Article Synopsis
- Giardiasis, caused by the parasite Giardia intestinalis, poses treatment challenges due to metronidazole resistance, but no markers for this resistance have been identified yet.
- This study examined 28 clinical samples from sub-assembly AII to assess variability in the flavohemoprotein gene's copy number, using digital PCR and next-generation sequencing, finding no link to metronidazole resistance.
- Results showed significant genetic diversity across Giardia sub-assemblages, with aneuploidy contributing to genomic variability, highlighting the need for more research to find reliable resistance markers despite advances in CNV analysis methods.
Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-eukaryotes, including Blastocystis, is underexplored. We performed a global-scale analysis on 56,989 metagenomes and showed that human Blastocystis exhibits distinct prevalence patterns linked to geography, lifestyle, and dietary habits.
View Article and Find Full Text PDFThe zoonotic parasite is a global cause of gastrointestinal disease in humans and ruminants. Sequence analysis of the highly polymorphic gene enabled the classification of isolates into multiple groups (e.g.
View Article and Find Full Text PDFWhile waters might be contaminated by oocysts from >40 Cryptosporidium species, only viable oocysts of C. parvum and C. hominis truly pose the main health risk to the immunocompetent population.
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- Echinococcus multilocularis is a parasitic cestode causing a deadly disease called alveolar echinococcosis, primarily spread by red foxes in Europe.
- The study investigated genetic diversity among E. multilocularis isolates from 19 European countries, analyzing 4,968 base pairs from five mitochondrial genes and identifying 43 different haplotypes.
- Findings indicated that most of the isolates shared four predominant haplotypes concentrated in mainland Europe, while Svalbard's isolates were genetically distinct, highlighting the need for more research in underrepresented eastern European regions to understand genetic variability.