Publications by authors named "S COSTA BOOCK"
Uterine serous carcinoma (USC) and uterine carcinosarcoma (UCS) tumors are uniquely aggressive, suggesting that the primary tumor is intrinsically equipped to disseminate and metastasize. Previous work identified mutational hotspots within PPP2R1A, which encodes the Aα scaffolding subunit of protein phosphatase 2A (PP2A), a heterotrimeric serine/threonine phosphatase. Two recurrent heterozygous PPP2R1A mutations, P179R and S256F, occur exclusively within high-grade subtypes of uterine cancer and can drive tumorigenesis and metastasis.
View Article and Find Full Text PDFMyeloid sarcoma (MS) represents a neoplastic proliferation characterized by immature myeloid precursor cells. Among its variants, aleukemic MS is an uncommon subtype, manifesting as skin involvement sparing the peripheral blood or bone marrow. The non-specific cutaneous presentation coupled with the lack of associated symptoms poses a diagnostic challenge for providers.
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- LARC (long-acting reversible contraception) is effective but often has limited accessibility and long wait times when referrals to specialists are necessary.
- A study implemented LARC services directly in a primary care practice (Practice A) to reduce these wait times, while a control group continued to refer patients to specialists (Practice B).
- Results showed that patients in Practice A experienced a significant reduction in wait times, completing procedures much faster than those in Practice B, highlighting the benefits of integrating LARC into primary care settings.