Publications by authors named "S C van Wees"
Background: Stroke prevalence is one of the most pressing issues in many sub-Saharan African countries. Stroke survivors often face disabilities, mental health problems, and experience stigma. Research on post-stroke experiences and interventions is limited, particularly in low and middle-income countries, including Ghana.
View Article and Find Full Text PDFMistreatment during institutional childbirth is multifactorial and can have a detrimental effect on women's health and future care-seeking behaviour. Understanding its determinants is essential for improving respectful maternity care. This study aimed to explore women's experiences of mistreatment during childbirth in Nepal.
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- The plant hormone abscisic acid (ABA) plays a key role in regulating plant development and stress responses by triggering a complex gene regulatory network involving many transcription factors (TFs) and genes.
- An RNA-seq time series identified 7151 differentially expressed genes in response to ABA treatment, which were organized into 44 coexpressed modules responsible for various biological functions.
- The study further analyzed TF regulation and interaction within the ABA gene regulatory network, highlighting the significance of the bZIP TF family and identifying GT3a as a positive regulator of drought tolerance, validated by drought assays.
Immune checkpoint inhibitors (ICI) have revolutionized the treatment landscape of advanced malignancies, but come with a diverse spectrum of immune-related adverse events (irAEs). Mechanistic studies can aid the transition from expert-opinion to evidence-based irAE treatment strategies. We aimed to longitudinally characterize peripheral blood T and B cell dynamics in ICI-treated patients by multicolor flow cytometry and serum multiplex immunoassay at baseline, ± 3 weeks and ± 6 weeks or upon clinically relevant irAEs.
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- Current whole sporozoite (SPZ) vaccines show limited effectiveness in malaria-endemic regions, possibly due to reduced immune responses from prior malaria exposure.
- Researchers have developed a method to enhance SPZ vaccine immunogenicity by attaching a TLR7 agonist-based adjuvant, leading to significantly higher immune responses, including a 35-fold increase in pro-inflammatory IL-6 production.
- Mice immunized with this enhanced SPZ vaccine demonstrated improved production of specific immune cells, suggesting that this chemical augmentation strategy could make malaria vaccines more effective.