Publications by authors named "S C Sundararaj"

Harnessing solar energy can be efficiently used to generate hydrogen by photochemical water splitting, which is a sustainable and environmentally benign energy source. Here, a unique visible-light-driven CoTiO@g-CN (CTOCN)-based photoanode interface has been optimized and developed with modification to follow the type II heterojunction for the enhancement of photoelectrochemical water splitting. Initially, a graphitic carbon nitride-loaded CoTiO (with 10 wt % g-CN) composite was obtained using a one-pot solvothermal method.

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A 38-year-old woman with papillary carcinoma of the thyroid who underwent total thyroidectomy followed by high-dose radioiodine ablation was called for Iodine-131 (I-131) whole-body follow-up scan. Her follow-up scan revealed focal tracer accumulation in the lower aspect of the right posterior neck region. Her stimulated serum thyroglobulin and anti-thyroglobulin antibodies were 0.

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Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements (CE) and the interaction with other TFs is unclear. Here, we report a distinct mechanism of TF alteration in human lymphomas with perturbed B cell identity, in particular classic Hodgkin lymphoma.

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Stress is a major determinant of health and wellbeing. Conventional stress management approaches do not account for the daily-living acute changes in stress that affect quality of life. The combination of physiological monitoring and non-invasive Peripheral Nerve Stimulation (PNS) represents a promising technological approach to quantify stress-induced physiological manifestations and reduce stress during everyday life.

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Article Synopsis
  • - Researchers discovered a recurrent mutation in the IRF4 gene, identified as p.T95R, linked to an autosomal dominant combined immunodeficiency (CID) in seven patients from six different families, leading to severe vulnerability to opportunistic infections and low antibody levels.
  • - The mutation caused significant defects in the maturation of B cells and alterations in T cell populations, resulting in impaired immune responses, as demonstrated in both human patients and a knock-in mouse model with similar symptoms.
  • - The altered IRF4 protein exhibited unusual behaviors, including stronger DNA binding but reduced activity on typical target genes, while also activating noncanonical genes, showcasing a complex interaction that disrupts normal immune function and leads to disease.
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