AD lesions and infarcts in demented and non-demented Japanese-American men.

Neocortical neuritic plaques and neurofibrillary tangles are hallmark neuropathological lesions of dementia. Concomitant cerebrovascular lesions increase dementia severity in patients meeting neuropathological criteria for Alzheimer's disease and contribute to cognitive impairment in persons with mild entorhinal Alzheimer lesions. This study investigates whether individuals with sparse neocortical neuritic plaques experience increased odds of crossing the threshold to clinical dementia when they have coexistent cerebrovascular lesions.

Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study.

Objective: To determine diagnostic accuracy for AD in a population-based study of Japanese-American men. AD is neuropathologically confirmed for more than 80% of cases at major referral centers (primarily Caucasians); however, information on diagnostic accuracy in population-based studies and studies of different ethnic groups is limited.

Methods: There were 3,734 men who participated in the Honolulu-Asia Aging Study 1991 through 1993 dementia examination and 2,603 in the 1994 through 1996 examination.

Genetic disease in offspring of long-term survivors of childhood and adolescent cancer.

Numerous case series have addressed the concern that cancer therapy may damage germ cells, leading to clinical disease in offspring of survivors. None has documented an increased risk. However, the methodological problems of small series make it difficult to draw firm conclusions regarding the potential of cancer treatments to damage the health of future offspring.

Marriage and divorce after childhood and adolescent cancer.

As part of a study of long-term survivors of childhood and adolescent cancer, we interviewed 2170 survivors and 3138 sibling control subjects about their marital histories. In a proportional hazards analysis, both male and female survivors were less likely to be ever married than control subjects (rate ratio [RR] for males, 0.87; 99% confidence interval, 0.

Improved survival among children with acute leukemia in the United States.

Statistically significant increases in 3- and 5-year survival rates were observed for white children under 15 years of age diagnosed with acute lymphocytic leukemia (ALL) from 1973-1976 to 1977-1980 in 9 geographic areas of the United States. Survival for the cohort diagnosed in 1977-1980 was 78% at 3 years, 68% at 5 years, and 42% at 10 years from diagnosis. For the cohort diagnosed in 1981-1984, however, slight but not significant decreases in survival rates were seen.