ST6GAL1-Mediated Sialylation of PECAM-1 Promotes a Transcellular Diapedesis-Like Process that Directs Lung Tropism of Metastatic Breast Cancer.

Metastasis is the leading cause of mortality in breast cancer, with lung metastasis being particularly detrimental. Identification of the processes determining metastatic organotropism could enable the development of approaches to prevent and treat breast cancer metastasis. Here, we found that lung-tropic and non-lung-tropic breast cancer cells differ in their response to sialic acids, affecting the sialylation of surface proteins.

Biomarkers.

Background: The relationships of left atrial (LA) dysfunction with cognition are poorly understood. We investigated the associations of LA function with cognitive impairment, etiologic-subtype (neurodegenerative vs. vascular[VCI]), neuroimaging markers of cerebrovascular disease (CeVD) and circulating biomarkers, in subjects without AF.

Public Health.

Background: People living with dementia and their carers, particularly those from culturally and linguistically diverse backgrounds, consistently demonstrate limited knowledge about and negative attitudes towards dementia. This can limit access to preventive and post-diagnostic care. Culturally sensitive dementia education is an inclusive and practical intervention that can be used in multicultural contexts to increase awareness and destigmatise the condition.

Biomarkers.

Background: The association between platelet endothelial cell adhesion molecule-1 (PECAM-1) with cerebral small vessel disease (CSVD) and cognition in non-demented subjects remains un-investigated.

Method: A longitudinal, prospective cohort of subjects recruited from memory clinics was followed-up for 5 years. Non-demented subjects were included and classified as no cognitive impairment (NCI) or mild cognitive impairment (MCI).

Developing Topics.

Background: Many carers of people living with dementia display misperceptions and negative attitudes about dementia due to limited education. This stigma can impact care and the accessibility of appropriate support services. Culturally diverse people living with dementia and their carers remain underserviced and lack culturally inclusive resources despite having specialised dementia needs.