Publications by authors named "S C Radu"
Article Synopsis
- Lactic acid bacteria (LAB) are beneficial in fermentation and as probiotics, producing antimicrobial compounds like bacteriocin-like inhibitory substance (BLIS) to enhance food safety.
- The study aimed to optimize a CRISPR/Cas9 system to redirect LAB metabolism by disrupting the lactate dehydrogenase gene (ldh), leading to higher yields of antimicrobial compounds.
- The modified LAB strains showed up to 78% increased inhibitory activity against foodborne pathogens, with Enterococcus faecalis-ldhΔ exhibiting notable bactericidal effects, marking a significant advancement in manipulating LAB metabolism for enhanced antimicrobial production.
Background: Social determinants of health (SDoH), including access to care, economic stability, neighborhood factors, and social context, strongly influence pediatric asthma outcomes. School-supervised asthma therapy (SST) is an evidence-based strategy that improves asthma outcomes, particularly for historically marginalized children, by providing support for daily medication adherence in school. However, little is known about the relationship between these programs and the adverse SDoH commonly affecting underrepresented minority and marginalized children with asthma.
View Article and Find Full Text PDFPoor adherence to inhaled corticosteroids (ICS) is a significant challenge in pediatric asthma, contributing to health inequities. Text-message reminders for ICS therapy are an evidence-based approach that improves pediatric asthma medication adherence, yet has not been widely adopted into practice, partly due to lack of (1) participant input on design and implementation and (2) use of sustainable community linkages. Remote Asthma Link™ (RAL) seeks to fill this gap as a school-linked text-message intervention wherein parents of children with poorly controlled asthma received daily, 2-way text-message reminders for preventive inhaler use.
View Article and Find Full Text PDFCellular asymmetry is an important element of efficiency in the compartmentalization of intracellular chemical reactions that ensure efficient tissue function. Improving the current 3D printing methods by using cellular asymmetry is essential in producing complex tissues and organs such as the liver. The use of cell spots containing at least two cells and basement membrane-like bio support materials allows cells to be tethered at two points on the basement membrane and with another cell in order to maintain cell asymmetry.
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