Publications by authors named "S C Radominski"
High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions.
Rheumatol Ther
February 2025
Article Synopsis
- RF titers are significant in the pathophysiology of rheumatoid arthritis (RA) and vary in their clinical impact, with high RF titers linked to poorer health outcomes.
- A study with 1,097 RA adults found a substantial portion had positive RF, with high titers prevalent, and identified associations of high RF with factors such as tobacco use and higher body mass index.
- High RF levels correlated with increased disease activity, reduced functional capacity, and greater use of corticosteroids and biological drugs, indicating a need for careful monitoring in RA patients.
Background: Infections increase mortality and morbidity and often limit immunosuppressive treatment in rheumatoid arthritis patients.
Objective: To analyze the occurrence of serious infections and the associated factors in a cohort of rheumatoid arthritis patients under real-life conditions.
Methods: We analyzed data from the REAL, a prospective observational study, that evaluated Brazilian RA patients, with clinical and laboratory data collected over a year.
Introduction: Although Rheumatoid Arthritis (RA) extra-articular manifestations (ExtRA) occurrence has been decreasing over time, they are still a major mortality risk factor for patients.
Objective: To determine the prevalence of ExtRA in a large cohort, and its association with demographic and clinical variables.
Method: Cross-sectional and observational study, based on a multi-centric database from a prospective cohort, in which 11 public rheumatology centres enrolled RA patients (1987 ARA or 2010 ACR-EULAR).
Do it fast! Early access to specialized care improved long-term outcomes in rheumatoid arthritis: data from the REAL multicenter observational study.
Adv Rheumatol
April 2023
Background: Early rheumatoid arthritis (RA) offers an opportunity for better treatment outcomes. In real-life settings, grasping this opportunity might depend on access to specialized care. We evaluated the effects of early versus late assessment by the rheumatologist on the diagnosis, treatment initiation and long-term outcomes of RA under real-life conditions.
View Article and Find Full Text PDFDecreasing delays in the diagnosis and treatment of rheumatoid arthritis in Brazil: a nationwide multicenter observational study.
Adv Rheumatol
February 2023
Background: Management delays imply worse outcomes in rheumatoid arthritis (RA) and, therefore, should be minimized. We evaluated changes in diagnostic and treatment delays regarding RA in the last decades in Brazil.
Methods: Adults fulfilling the ACR/EULAR (2010) criteria for RA were assessed.