GSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments.

The pathological deposition of proteins is a hallmark of several devastating neurodegenerative diseases. These pathological deposits comprise aggregates of proteins that adopt distinct structures named strains. However, the molecular factors responsible for the formation of distinct aggregate strains are unknown.

Nutritional Guidelines for Patients with Type 1 Diabetes Mellitus and its Adherence- A Narrative Review.

Nutritional guidelines are of importance in directing food choices of T1D patients. The objective is to summarise existing nutritional recommendations and examine its adherence by T1D patients. Literature was searched on dietary guidelines in T1D using electronic databases PubMed, Science Direct, Scopus, Google Scholar, in English and 29 papers were selected.

Transformative Role of Artificial Intelligence in Reporting Haematology Cases: A Case Report.

Artificial intelligence (AI) is transforming haematology reporting by improving accuracy, standardisation, and speed, addressing the need for timely and precise diagnostics. This study explores the use of the AI100 (SigTuple Technologies Private Limited, Bangalore, India) automated machine, a smart robotic microscope designed to automate the microscopic analysis of peripheral blood smears. Through the analysis of four haematology cases, this study demonstrates how AI technology facilitates efficient cell identification, enhances risk stratification, enables early detection of abnormalities, and accelerates diagnostic turnaround times.

Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer.

Neuroendocrine and tuft cells are rare, chemosensory epithelial lineages defined by expression of ASCL1 and POU2F3 transcription factors, respectively. Neuroendocrine cancers, including small cell lung cancer (SCLC), frequently display tuft-like subsets, a feature linked to poor patient outcomes. The mechanisms driving neuroendocrine-tuft tumour heterogeneity, and the origins of tuft-like cancers are unknown.

TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages.

The RNA binding protein TIA1 is known to regulate stress responses. Here we show that TIA1 plays a much broader role in inflammatory cells, being required for the microglial sensome. We crossed TIA1 cKO mice (using a CX3CR1 driven cre element) to PS19 MAPT P301S tauopathy mice.