Publications by authors named "S C Pappas"
The Chairperson of the Commission on Magnet®, Dr Sharon Pappas, discusses her history in leadership and the role of Magnet designation on her trajectory. Dr Pappas presents her thoughts about the direction of the Commission on Magnet for the future, based on the successes of the past.
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- The inferior olive (IO) is a key brainstem region affected by spinocerebellar ataxias (SCAs), impacting motor learning, but its degeneration mechanisms remain unclear.
- Researchers studied SCA1 using a genetically modified mouse model (SCA1-KI) and found that these mice show olivary hypertrophy similar to hypertrophic olivary degeneration (HOD), with early neuronal changes but no loss of cells.
- The SCA1-KI IO neurons are hyperexcitable and have reduced expression of ion channels that typically regulate their activity, indicating a dysregulation linked to mutant ataxin-1 expression in these neurons.
Pancreatic ductal adenocarcinoma (PDAC) stands out as one of the most aggressive and challenging tumors, characterized by a bleak prognosis with a mere 11% survival rate over 5 years in the United States. Its formidable nature is primarily attributed to its highly aggressive behavior and poor response to existing therapies. PDAC, being notably resistant to immune interventions, presents a significant obstacle in treatment strategies.
View Article and Find Full Text PDFAlthough the spatial, cellular and molecular landscapes of resected pancreatic ductal adenocarcinoma (PDAC) are well documented, the characteristics of its metastatic ecology remain elusive. By applying spatially resolved transcriptomics to matched primary and metastatic PDAC samples, we discovered a conserved continuum of fibrotic, metabolic and immunosuppressive spatial ecotypes across anatomical regions. We observed spatial tumor microenvironment heterogeneity spanning beyond that previously appreciated in PDAC.
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