Publications by authors named "S C Oehninger"
Article Synopsis
- The study aimed to determine if SARS-CoV-2 is present in the semen of men during the acute phase of COVID-19.
- A total of twenty-two men with confirmed COVID-19 were analyzed, with semen samples collected at 7, 14, and 21 days post-infection to check for the virus and assess seminal parameters.
- The results showed no presence of SARS-CoV-2 in any semen samples, indicating that men with mild COVID-19 are unlikely to transmit the virus through semen.
Article Synopsis
- The study examines how transferring more embryos during IVF and the number of fetal heartbeats at 6 weeks can impact birth outcomes.
- Analyzed data from over 138,000 live births across multiple states indicated that having excess embryos and heartbeats correlates with higher risks of birth defects, low birthweight, and preterm births.
- The findings suggest that transferring more embryos increases adverse perinatal outcomes in both singleton and twin births, emphasizing the need for cautious embryo transfer practices in IVF.
Study Question: What is the association between ART conception and treatment parameters and the risk of birth defects?
Summary Answer: Compared to naturally conceived singleton infants, the risk of a major nonchromosomal defect among ART singletons conceived with autologous oocytes and fresh embryos without use of ICSI was increased by 18%, with increases of 42% and 30% for use of ICSI with and without male factor diagnosis, respectively.
What Is Known Already: Prior studies have indicated that infertility and ART are associated with an increased risk of birth defects but have been limited by small sample size and inadequate statistical power, failure to differentiate results by plurality, differences in birth defect definitions and methods of ascertainment, lack of information on ART treatment parameters or study periods spanning decades resulting in a substantial historical bias as ART techniques have improved.
Study Design, Size, Duration: This was a population-based cohort study linking ART cycles reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) from 1 January 2004 to 31 December 2015 that resulted in live births from 1 September 2004 to 31 December 2016 in Massachusetts and North Carolina and from 1 September 2004 to 31 December 2015 for Texas and New York: these were large and ethnically diverse States, with birth defect registries utilizing the same case definitions and data collected, and with high numbers of ART births annually.
Importance: Children with birth defects have a greater risk of developing cancer, but this association has not yet been evaluated in children conceived with in vitro fertilization (IVF).
Objective: To assess whether the association between birth defects and cancer is greater in children conceived via IVF compared with children conceived naturally.
Design, Setting, And Participants: This cohort study of live births, birth defects, and cancer from Massachusetts, New York, North Carolina, and Texas included 1 000 639 children born to fertile women and 52 776 children conceived via IVF (using autologous oocytes and fresh embryos) during 2004-2016 in Massachusetts and North Carolina, 2004-2015 in New York, and 2004-2013 in Texas.