Using qualitative approaches to improve quantitative inferences in environmental psychology.

This article describes the qualitative approach used to generate and interpret the quantitative study reported by Song and colleagues' (2020) in their article, "What counts as an 'environmental' issue? Differences in environmental issue conceptualization across race, ethnicity, and socioeconomic status." Song and colleagues (2020) describe the results of a survey documenting that, in the United States, White and high-SES respondents perceive environmental issues differently than their non-White and lower-SES counterparts, reflecting structural differences in environmental risks. While Song and colleagues (2020) discuss the survey results in detail, the discussion of the qualitative research that led to the creation of that survey was limited due to space constraints.

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα.

The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling, known to regulate multiple metabolic pathways. SIRT6 binds PPARα and its response element within promoter regions and activates gene transcription.

SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan.

The extension in human lifespan in the last century results in a significant increase in incidence of age related diseases. It is therefore crucial to identify key factors that control elderly healthspan. Similar to dietary restriction, mice overexpressing the NAD+ dependent protein deacylase SIRT6 (MOSES) live longer and have reduced IGF-1 levels.

ModuleBlast: identifying activated sub-networks within and across species.

Identifying conserved and divergent response patterns in gene networks is becoming increasingly important. A common approach is integrating expression information with gene association networks in order to find groups of connected genes that are activated or repressed. In many cases, researchers are also interested in comparisons across species (or conditions).