A Combined Approach to Extract Rotational Dynamics of Globular Proteins Undergoing Liquid-Liquid Phase Separation.

The formation of protein condensates (droplets) via liquid-liquid phase separation (LLPS) is a commonly observed phenomenon in vitro. Changing the environmental properties with cosolutes, molecular crowders, protein partners, temperature, pressure, etc. has been shown to favor or disfavor the formation of protein droplets by fine-tuning the water-water, water-protein, and protein-protein interactions.

Nonlinear switch and spatial lattice solitons of photonic - orbitals.

We develop fs laser-fabricated asymmetric couplers and zig-zag arrays consisting of single- and two-mode waveguides with bipartite Kerr nonlinearity in borosilicate (BK7) glass substrates. The fundamental mode ( orbital) is near resonance with the neighboring higher-order orbital, causing efficient light transfer at low power. Due to Kerr nonlinearity, the coupler works as an all-optical switch between and orbitals.

Atmospheric nitrogen oxides (NO), hydrogen sulphide (HS) and carbon monoxide (CO): Boon or Bane for plant metabolism and development?

Urban air pollution has been a global challenge world-wide. While urban vegetation or forest modelling can be useful in reducing the toxicities of the atmospheric gases by their absorption, the surge in gaseous pollutants negatively affects plant growth, thereby altering photosynthetic efficiency and harvest index. The present review analyses our current understanding of the toxic and beneficial effects of atmospheric nitrogen oxides (NO), hydrogen sulphide (HS) and carbon monoxide (CO) on plant growth and metabolism.

Exploring target selectivity in designing and identifying PI3Kα inhibitors for triple negative breast cancer with fragment-based and bioisosteric replacement approach.

Triple-negative breast cancer (TNBC) is one of the most fatal malignancies in the world, accounting for 42% of all deaths due to metastasis. The significant development is hindered by the multi-drug resistance and poor patient compliance. PIK3CA gene mutation is one of the important causes of TNBC, which causes dysregulation of the cell cycle and cell proliferation.

Non-Alcoholic Fatty Liver Disease Among Newly Diagnosed Type 2 Diabetes Mellitus in North Bihar and Missed Opportunities for Early Diagnosis.

Background: There are no studies investigating missed opportunities for earlier diagnosis in newly/recently detected Type 2 Diabetes Mellitus and Non-alcoholic Fatty Liver Disease in the region of Bihar, India.

Methods: This study is a single-center cross-sectional study undertaken at the Research Centre for Diabetes Hypertension and Obesity, Samastipur, Bihar, India. The study collected data from newly/recently diagnosed persons with T2DM.