Publications by authors named "S C McCloskey"
Bacterial levans are biopolymers composed of fructose units linked by β-2,6 glycosidic bonds that are degradable, nontoxic and flexible, representing a green technology with significant applications across various industries. Fermented soybeans are a common source of bacteria-producing polysaccharides. In this study, KKSB4, KKSB6 and KKSB7 isolated from traditionally fermented soybean (Thua-nao), along with strain 5.
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- - The study examined the chemical diversity of the SWUF15-40 fungus grown in a yeast-malt extract medium, shifting from the previous PDB medium using the OSMACs strategy, which resulted in discovering numerous bioactive compounds.
- - Detailed analysis using IR, NMR, MS, and XRD techniques led to the identification of two new isopimarane derivatives, three guaiane derivatives, and four known compounds.
- - A cyclic pentapeptide from the fungus showed promising anti-cancer activity against several cell lines and inhibited nitric oxide production, indicating that adjusting growth conditions can enhance the discovery of bioactive compounds in fungi.
Two new compounds, 6-hydroxy-1-(4-hydroxyphenyl)naphtho[2,1-]furan-2,5-dion () and 3-methyl-6--L-rhamnopyranosyl-2-chromen-2-one (), along with three known compounds (-) were isolated from the rare bambusicolous fungus . The structures were elucidated through the analysis of IR, NMR and HRESIMS spectrographic data. Compound exhibited cytotoxicity against HeLa, HT29, MCF-7 and PC-3 cells, but was not toxic against normal Vero cells.
View Article and Find Full Text PDFManuka honey (MH) exhibits potential antitumor activity in preclinical models of a number of human cancers. Treatment in vitro with MH at concentrations ranging from 0.3 to 5.
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- Breast cancer treatment involves a team of specialists from surgical, radiation, and medical oncology fields.
- The NCCN Guidelines provide recommendations for various types of breast cancer, including different stages and specific conditions like Paget's disease and treatment during pregnancy.
- This issue highlights the management of systemic therapies for nonmetastatic breast cancer, both before and after surgery.