Publications by authors named "S C Mack"
Objective: The purpose of this study is to utilize a representative national sample to compare survival outcomes of patients with visceral pleural invasion (VPI) who underwent either a lobectomy or a segmentectomy.
Methods: National Cancer Database from 2010 to 2019 was utilized. Patients with tumor size ≤ 2 cm, with VPI, non-small cell lung cancer (NSCLC), with a known vital status were included in the study.
Article Synopsis
- Medulloblastoma and ependymoma are common types of brain tumors in children, and this study analyzes their molecular differences using bulk RNA sequencing data from a large number of tumor samples.
- The researchers processed the data to create a unified landscape, identifying distinct gene expression profiles and molecular characteristics within the tumors, particularly highlighting two compartments in ependymoma and subtypes in medulloblastoma.
- The findings provide a valuable resource for discovering new biomarkers and improving diagnostic accuracy, and the data can be explored using the interactive platform Oncoscape for better patient classification in future research.
Immune synapse (IS) formation determines T cell antitumor activity. Here, we present a protocol for characterizing the IS formation between chimeric antigen receptor (CAR) T cells and tumor cells by measuring the IS size and calcium flux by live-cell imaging. We describe steps for CAR T cell manufacturing, sample preparation, image acquisition, and data analysis.
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- The DPB1 locus shows allele frequencies influenced by genetic drift, but specific amino acids at this locus are shaped by balancing selection, suggesting a complex relationship between drift and selection in genetic diversity.
- Using Ewens-Watterson and asymmetric Linkage Disequilibrium analyses across 136 global populations, researchers found strong evidence of balancing selection affecting DP serologic categories (SCs), while no similar selection was observed for T-cell epitopes or supertypes.
- The distribution of different SCs varies globally, with specific SCs prevalent in distinct regions, and the study highlights consistent associations between DPA1 and DP SC haplotypes, indicating that natural selection is primarily acting to preserve diversity in DP SCs rather than DPB1 alle
Article Synopsis
- The study aimed to analyze how Medicaid expansion impacted the receipt of adjuvant chemotherapy among eligible cancer patients using a national database.
- Researchers reviewed data from nearly 10,000 patients treated in states that expanded Medicaid, finding a significant increase in chemotherapy receipt post-expansion (70.2% vs. 62.3%).
- The results suggest that Medicaid expansion improved access to care and potentially led to better survival outcomes for patients receiving adjuvant therapy.