Publications by authors named "S C M Wuyts"
Dose-Limiting Toxicities of Paclitaxel in Breast Cancer Patients: Studying Interactions Between Pharmacokinetics, Physical Activity, and Body Composition-A Protocol for an Observational Cohort Study.
Cancers (Basel)
December 2024
: Paclitaxel (PTX), a commonly used chemotherapy for breast cancer (BC), is associated with dose-limiting toxicities (DLTs) such as peripheral neuropathy and neutropenia. These toxicities frequently lead to dose reductions, treatment delays, or therapy discontinuation, negatively affecting patients' quality of life and clinical outcomes. Current dosing strategies based on body surface area (BSA) fail to account for individual variations in body composition (skeletal muscle mass (SMM) and adipose tissue (AT) mass) and physical activity (PA), which can influence drug metabolism and toxicity.
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- The study aimed to compare how well calcium citrate and calcium carbonate are absorbed after different weight loss surgeries: Roux-en-Y gastric bypass, laparoscopic sleeve gastrectomy, and one-anastomosis gastric bypass.
- It involved 150 participants, focusing on measuring calcium levels in blood and urine, as well as parathyroid hormone levels, over a controlled testing period.
- Results showed that calcium citrate resulted in lower parathyroid hormone levels and better calcium absorption than calcium carbonate, indicating it may be the more effective supplement post-surgery.
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- Recent observations from the James Webb Space Telescope (JWST) have found many massive-galaxy candidates in the early Universe, stretching further back in time and at lower brightness levels than previously seen.
- These findings initially posed challenges to the Λ cold dark-matter model, but the new study's results show no significant conflicts when accounting for spectroscopic redshifts.
- The research highlights three ultra-massive galaxies that convert a notably high percentage of baryons into stars, suggesting they play a significant role in cosmic star-formation rates at redshifts 5 to 6.
Objective: Intravenous (IV) fluid therapy is a known source of iatrogenic complications. Guideline implementation can be used to educate and guide physicians on adequate fluid management. In the emergency department (ED), a complex and interruption-driven environment, workload is high and active documentation is required to facilitate audits of fluid management quality.
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- The study focused on how a pharmacist-led care program can help reduce drug-related problems (DRPs) for orthogeriatric patients after they are discharged from the hospital.
- 127 patients participated, with the intervention group showing a significant reduction in DRPs compared to the control group, indicating the pharmacist's role was beneficial.
- The results suggested that the majority of the pharmacist's interventions were accepted by general practitioners, and many had a clinical impact, which could help prevent further complications post-discharge.