Publications by authors named "S C M O'Hara"
Article Synopsis
- Regulatory T (Treg) cells are crucial for maintaining immune tolerance during pregnancy, ensuring that the mother’s body accepts the developing fetus and placenta.
- In a study using a specific mouse model, researchers found that depleting Treg cells early in pregnancy led to problems with the remodeling of uterine arteries, reduced natural killer (uNK) cell numbers, and resulted in fetal loss and growth restriction.
- By transferring Treg cells from healthy donors, the negative effects on vascular function and fetal health were mitigated, highlighting the important role Treg cells play in adapting the uterine environment for a successful pregnancy and their connection to issues like preeclampsia.
A Review of Meta-Analyses of Prevention Strategies for Problematic Cannabis Use.
Curr Addict Rep
October 2024
Purpose Of Review: This narrative review summarizes research-to-date on strategies to prevent problematic cannabis use.
Recent Findings: Ten meta-analytic reviews of cannabis use prevention strategies published after 2010 were identified for this review. The meta-analytic reviews were based on studies evaluating the effectiveness of school-based programs, online/digital interventions, mass-media approaches, culturally specific interventions, and brief interventions.
Introduction/purpose: The coronavirus disease (COVID-19) is a widely spread viral infectious disease, which can impact multiple organs, including the liver. Elevated liver enzymes have been reported in COVID-19 patients; however, potential changes in liver stiffness following the viral infection remain uncertain. The main aim of this pilot study was to determine if there is a significant difference in liver stiffness between individuals who have never been infected with COVID-19 and those who had been infected with COVID-19 <6 months, experiencing only mild symptoms.
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- - Senescent cells release inflammatory signals known as the senescence-associated secretory phenotype (SASP), which are linked to aging and tissue dysfunction.
- - Mitochondrial RNA (mtRNA) accumulates in these cells and activates RNA sensors, triggering the aggregation of MAVS and enhancing SASP production.
- - Targeting the RNA sensors and understanding the role of proteins like BAX and BAK can potentially reduce SASP factors and age-related inflammation, suggesting new treatment approaches for conditions like Metabolic Dysfunction Associated Steatohepatitis (MASH).
Cholangiopathies comprise a spectrum of chronic intrahepatic and extrahepatic biliary tract disorders culminating in progressive cholestatic liver injury, fibrosis, and often cirrhosis and its sequela. Treatment for these diseases is limited, and collectively, they are one of the therapeutic "black boxes" in clinical hepatology. The etiopathogenesis of the cholangiopathies likely includes disease-specific mediators but also common cellular and molecular events driving disease progression (eg, cholestatic fibrogenesis, inflammation, and duct damage).
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