Publications by authors named "S C Levine"
Background: The levels of biogenesis of lysosome organelles complex 1 subunit 1 (BLOC1S1) control mitochondrial and endolysosome organelle homeostasis and function. Reduced fidelity of these vacuolar organelles is increasingly being recognized as important in instigating cell-autonomous immune cell activation. We reasoned that exploring the role of BLOC1S1 in CD4 T cells may further advance our understanding of regulatory events linked to mitochondrial and/or endolysosomal function in adaptive immunity.
View Article and Find Full Text PDFPatients receiving palliative care experience stigma associated with their illness, personal identity, and healthcare utilization. These stigmas can occur at any stage of the disease process. Varying stigmas combine to cause palliative care patients to feel misunderstood, contribute to treatment barriers, and further negative stereotypes held by clinicians.
View Article and Find Full Text PDFA new perspective on the causal pathway between maternal mental health and neonatal adversity.
Arch Womens Ment Health
December 2024
Article Synopsis
- - The study investigates how maternal mental health affects birth outcomes, particularly looking at complications and congenital anomalies in newborns, while accounting for maternal physical health and family background.
- - Using data from over 74,000 children born between 1997-2008 in Israel, the researchers found significant links between maternal mental health issues during pregnancy and negative neonatal outcomes, although these links weakened when considering maternal physical health.
- - The findings suggest that both maternal and paternal mental health diagnoses independently contribute to adverse birth outcomes, highlighting the importance of addressing physical health and family dynamics in understanding these associations.
Addressing drug-induced liver injury is crucial in drug development, often causing Phase III trial failures and market withdrawals. Traditional animal models fail to predict human liver toxicity accurately. Virtual twins of human organs present a promising solution.
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