Publications by authors named "S C Just"
Article Synopsis
- - The resolution in magnetic resonance imaging (MRI) is often hindered by low signal-to-noise ratio (SNR) and can be improved through longer scan times or specialized hardware, especially at single-digit micron levels.
- - A new microscopy insert has been developed to achieve high resolutions in horizontal preclinical imaging systems, featuring an efficient gradient and a low noise amplifier for better SNR in small samples.
- - This setup has demonstrated enhanced imaging capabilities, using a modified imaging sequence to capture ultra-high-resolution images of zebrafish embryos at a resolution of (9 μm)³.
TRPC4/5 inhibitors: Phase I results and proof of concept studies.
Eur Arch Psychiatry Clin Neurosci
September 2024
Transient receptor potential canonical (TRPC) ion channels are expressed in areas of the brain responsible for processing emotion and mood and have been implicated in the pathophysiology of internalizing disorders such as major depressive disorder and anxiety disorders. This review outlines the rationale for targeting TRPC ion channels for drug development, with specific focus on TRPC4 and TRPC5. We provide preclinical evidence that the lack of TRPC4 and TRPC5 channels or its pharmacological inhibition attenuate fear and anxiety without impairing other behaviors in mice.
View Article and Find Full Text PDFIntroduction: The psychic structure of people with psychosis has been the subject of theoretical and qualitative considerations. However, it has not been sufficiently studied quantitatively. Therefore, the aim of this study was to explore the structural abilities of people diagnosed with schizophrenia and schizoaffective psychosis using the Levels of Structural Integration Axis of the Operationalized Psychodynamic Diagnosis System (OPD-2-LSIA).
View Article and Find Full Text PDFArticle Synopsis
- Hospitalization rates for childhood pneumonia show significant variation, and a study aimed to test if a risk-based clinical decision support (CDS) system could help standardize care in pediatric emergency departments.
- The study involved 536 patient encounters, comparing usual care to an EHR-integrated CDS tool that used a pneumonia severity score; results showed no significant difference in inappropriate patient disposition between the two groups.
- While the CDS tool received positive feedback from clinicians, challenges in implementation and low patient enrollment likely hindered its effectiveness in improving decision-making around ED care for pneumonia.