Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity.

Neurodegeneration in central nervous system disorders is linked to dysregulated neuronal calcium. Direct inhibition of glutamate-induced neuronal calcium influx, particularly via N-methyl-D-aspartate receptors (NMDAR), has led to adverse effects and clinical trial failures. A more feasible approach is to modulate NMDAR activity or calcium signaling indirectly.

Diets, fruit and vegetables consumption, and nutritional status in Benin: A scoping review.

Unhealthy diets, including low fruit and vegetables (F&V) intake, contribute to morbidity and mortality related to non-communicable diseases. Designing culturally appropriate interventions to improve diets and F&V intake requires an in-depth understanding of individual-level dietary patterns, household consumption patterns, and nutritional status resulting from inadequate F&V intake. In this scoping review, we summarised the literature on diets, F&V intake, and nutritional status in Benin.

Diets, Fruit and Vegetable Intake and Nutritional Status Among Children, Adolescents and Adults in the Philippines: A Scoping Review.

Suboptimal diets contribute to the risk of malnutrition and non-communicable diseases across the life course. Globally, intakes of fruit and vegetables (F&V) fall below recommendations, including in the Philippines. To promote F&V intakes, understanding the extent of inadequate intakes across population groups and key drivers of dietary patterns is needed.

Diets, Fruit and Vegetable Intake and Nutritional Status in Tanzania: Scoping Review.

Globally, the intake of fruit and vegetables (F&V) is far below the recommended levels, contributing to various health challenges including micronutrient deficiencies and non-communicable diseases. In Tanzania, where the triple burden of malnutrition persists, there is a need to identify gaps in evidence, better understand diets and F&V intake and identify promising interventions for improved intake. We conducted a scoping review to summarize the evidence on dietary intake, F&V intake and nutritional status in Tanzania.

New York State Climate Impacts Assessment Chapter 05: Ecosystems.

The people of New York have long benefited from the state's diversity of ecosystems, which range from coastal shorelines and wetlands to extensive forests and mountaintop alpine habitat, and from lakes and rivers to greenspaces in heavily populated urban areas. These ecosystems provide key services such as food, water, forest products, flood prevention, carbon storage, climate moderation, recreational opportunities, and other cultural services. This chapter examines how changes in climatic conditions across the state are affecting different types of ecosystems and the services they provide, and considers likely future impacts of projected climate change.