Publications by authors named "S C Gough"
Police officers often face critical incidents involving armed offenders, requiring the use of force to ensure safety. Eyewitness accounts, including those from officers, are crucial in the justice system but can be unreliable. Techniques such as self-authored statements and structured interviews are used to gather information, but their efficacy in high-stress situations is unclear.
View Article and Find Full Text PDFOncogenic RAS-induced senescence (OIS) is an autonomous tumour suppressor mechanism associated with premalignancy. Achieving this phenotype typically requires a high level of oncogenic stress, yet the phenotype provoked by lower oncogenic dosage remains unclear. Here we develop oncogenic RAS dose-escalation models in vitro and in vivo, revealing a RAS dose-driven non-linear continuum of downstream phenotypes.
View Article and Find Full Text PDFArticle Synopsis
- Estrogen receptor (ER) alpha is a key factor in ER+/HER2- breast cancer, and combining current therapies with new drugs is essential due to resistance issues like ESR1 mutations.
- Vepdegestrant (ARV-471) is a new drug that efficiently degrades both wild-type and mutant ER, showing significant tumor growth inhibition in various breast cancer models, outperforming the standard treatment fulvestrant.
- The study suggests that vepdegestrant could be a more effective treatment option for patients with ER+/HER2- breast cancer, especially when combined with other therapies like CDK4/6, mTOR, or PI3K inhibitors.
Background: Mandatory training is considered fundamental to establishing and maintaining high standards of professional practice. There is little evidence however, of the training either achieving its required learning outcomes, or delivering improvement in outcomes for patients. Whist organisations may be hitting their compliance target for mandatory training, is the purpose missing the point? This systematic review aims to synthesize and evaluate the efficacy of statutory and mandatory training.
View Article and Find Full Text PDFObjective: To determine the sodium correction factor for clinical use in hyperglycemic diabetic dogs.
Sample: Retrospective analysis of 76 hospitalization episodes from 67 different dogs presenting to the University of Georgia Veterinary Teaching Hospital between January 1, 2015, and January 1, 2023.
Methods: For each hospitalization episode, paired blood sodium and glucose concentration measurements were recorded from the time of presentation until glucose concentration was ≤ 201 mg/dL.