Bioinformatic identification of important roles of COL1A1 and TNFRSF12A in cartilage injury and osteoporosis.

Objective: The aim of this study was to identify the key regulatory mechanisms of cartilage injury and osteoporosis through bioinformatics methods, and to provide a new theoretical basis and molecular targets for the diagnosis and treatment of the disease.

Methods: Microarray data for cartilage injury (GSE129147) and osteoporosis (GSE230665) were first downloaded from the GEO database. Differential expression analysis was applied to identify genes that were significantly up-or down-regulated in the cartilage injury and osteoporosis samples.

Maximizing Output Energy via Suppressing Charge Loss and Increasing Load Voltage in Charge Extraction Process.

The effective collection of interfacial tribo-charges and an increase in load voltage are two essential factors that improve the output energy of triboelectric nanogenerators. However, some tribo-charges are hardly collected through one or multiple integrated side electrodes based on corona discharge, and their load voltages are limited by air breakdown in adjacent electrodes. In this study, a dynamic quasi-dipole potential distribution model is proposed to systematically reveal the mechanisms of interfacial tribo-charge loss.

Global temporal trends and projections of hepatitis B-related cirrhosis among adolescents and young adults from 1990 to 2035: an analysis based on the global burden of disease study 2021.

Background: Chronic hepatitis B and cirrhosis pose significant global health threats. Few studies have explored the disease burden and mortality trend of cirrhosis caused by hepatitis B virus infection among adolescents and young adults (AYAs, aged 15-39 years). This study aimed to assess the disease burden and trends.

[Analysis of clinical features and prognostic factors of focal cerebral arteriopathy in children].

To summarize the clinical characteristics of focal cerebral arteriopathy (FCA) in children, and to analyze its influencing factor of prognosis. A retrospective cohort study was conducted. Clinical data from 40 children with FCA who were hospitalized at the Department of Neurology, Beijing Children's Hospital, Capital Medical University, from September 2015 to August 2024 were collected.

Dual-State Emissive Mitochondrial Viscosity Probe for Long-Term Imaging of Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is a destructive autoimmune disease that seriously affects human health. Due to the lack of a cure for RA, a good prognosis largely depends on early diagnosis and effective treatment monitoring of RA. Therefore, the development of fluorescent probes capable of real-time detection of RA is of great significance.