Engineered ipilimumab variants that bind human and mouse CTLA-4.

Testing of candidate monoclonal antibody therapeutics in preclinical models is an essential step in drug development. Identification of antibody therapeutic candidates that bind their human targets and cross-react to mouse orthologs is often challenging, especially for targets with low sequence homology. In such cases, surrogate antibodies that bind mouse orthologs must be used.

AI as your ally: The effects of AI-assisted venting on negative affect and perceived social support.

In recent years, artificial intelligence (AI) chatbots have made significant strides in generating human-like conversations. With AI's expanding capabilities in mimicking human interactions, its affordability and accessibility underscore the potential of AI chatbots to facilitate negative emotional disclosure or venting. The study's primary objective is to highlight the potential benefits of AI-assisted venting by comparing its effectiveness to venting through a traditional journaling platform in reducing negative affect and increasing perceived social support.