Publications by authors named "S C Dinescu"
Objectives: To quantify levels of two inflammation-related indexes, namely neutrophil-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) in systemic scleroderma patients and determine the association with clinical manifestations and features of heart ultrasound.
Methods: The study group consisted of 34 patients with diagnosis of systemic scleroderma which were admitted to the hospital during 2015-2019. Patient data included the presence and type of clinical manifestations of systemic scleroderma, chest imaging to screen for lung disease, heart ultrasound reports and the laboratory investigations needed to quantify inflammatory indexes.
Article Synopsis
- The study aimed to assess the potential of vitamin D, the neutrophil to lymphocyte ratio (NLR), and the systemic inflammation index (SII) as biomarkers for identifying flares in systemic lupus erythematosus (SLE).
- Researchers conducted a thorough examination and analyzed blood samples from individuals with SLE to evaluate their disease activity using established criteria (EULAR/ACR 2019).
- Results indicated that both NLR and SII are strong predictors of severe disease flares, while vitamin D levels showed a weaker connection to disease severity, suggesting a need for more research on its role.
Background: Systemic sclerosis (SSc) is a complex connective tissue disease characterized by microangiopathy, immune dysregulation, and fibrosis. Early detection of microvascular abnormalities using nailfold videocapillaroscopy (NVC) is crucial in assessing disease progression and associated disease's involvement such as interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH).
Objective: This study aims to explore the relationships correlation between NVC patterns, clinical manifestations, and systemic complications in SSc.
Chronic inflammation and NLRP3 inflammasome activation are among the determining factors of breast malignancies. Paclitaxel (PTX) is a drug used in breast cancer treatment which sustains prolonged inflammation, reducing the effectiveness of chemotherapy. Considering the impact of inflammatory processes in cancer progression, there is a strong concern to develop therapeutic strategy targeting NLRP3 inflammasome for triple-negative breast cancer (TNBC) treatment.
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- A study involving 65 gout patients and 40 healthy individuals investigated the presence of subclinical carotid atherosclerosis, which is a risk factor for cardiovascular disease, through ultrasound examinations.
- The findings showed a significantly higher prevalence of increased carotid intima-media thickness (CCAIMT) and carotid plaques in gout patients compared to the controls, indicating a potential connection between gout and cardiovascular risks.
- Various factors, such as serum uric acid levels, age, disease duration, and low-density lipoprotein cholesterol, were found to independently contribute to the increased carotid thickness and plaque formation in gout patients, emphasizing the usefulness of carotid ultrasound as a diagnostic tool.