A "Mismatched" connection: a rare case of indirect or dural carotid-cavernous fistula: a case based review.

Introduction And Importance: A carotid-cavernous sinus fistula is an abnormal connection between the internal or external carotid artery and the venous system of the cavernous sinus. It represents a rare entity, and it is often misdiagnosed due to its overlapping symptoms with other conditions such as cavernous sinus thrombosis or orbital inflammation. Cerebral angiography continues to be the gold standard for diagnosis and surgical planning in patients with CCF, and the endovascular trans-venous approach still represents the primary line of treatment.

α-D NUCLEOSIDE BASED SELF-HEALING SUPRAMOLECULAR HYDROGELS DERIVED FROM THE α-D ANOMERS OF 2'-DEOXYGUANOSINE AND FLUORESCENT 8-AZAPURINE 2'-DEOXYRIBOFURANOSIDES.

Self-assembly of α-D nucleosides to supramolecular hydrogels is described in detail. Hydrogel formation was studied on α-D 2'-deoxyguanosine (α-dG), and the fluorescent 8-azapurine α-D nucleosides 2-amino-8-aza-2'-deoxyadenosine (α-2-NH2-z8Ad) and 8-aza-2'-deoxyisoguanosine (α-z8iGd). These compounds were prepared from α-D 8-aza-2'-deoxyguanosine by an activation/amination protocol followed by deamination.

Association of Antibody-Drug Conjugate (ADC) Target Expression and Interstitial Lung Disease (ILD) in Non-Small-Cell Lung Cancer (NSCLC): Association or Causation or Neither?

Introduction: Non-small-cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, despite advances in immune checkpoint inhibitors and targeted therapies. Antibody-drug conjugates (ADCs) represent a promising therapeutic approach by delivering cytotoxic agents specifically to cancer cells, potentially reducing harm to healthy tissues. This study aims to explore the effectiveness and challenges associated with ADCs in NSCLC, with a focus on drug-induced interstitial lung disease (D-ILD).