Publications by authors named "S C Clifford"
Background: In a world confronted with new and connected challenges, novel strategies are needed to help children and adults achieve their full potential, to predict, prevent and treat disease, and to achieve equity in services and outcomes. Australia's Generation Victoria (GenV) cohorts are designed for multi-pronged discovery (what could improve outcomes?) and intervention research (what actually works, how much and for whom?). Here, we describe the key features of its protocol.
View Article and Find Full Text PDFWe profiled a large heterogenous cohort of matched diagnostic-relapse tumour tissue and paired plasma-derived cell free DNA (cfDNA) from patients with relapsed and progressive solid tumours of childhood. Tissue and cfDNA sequencing results were concordant, with a wider spectrum of mutant alleles and higher degree of intra-tumour heterogeneity captured by the latter, if sufficient circulating tumour-derived DNA (ctDNA) was present. Serial tumour sequencing identified putative drivers of relapse, with alterations in epigenetic drivers being a common feature.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to explore the long-term impacts of COVID-19 on key vascular structures and clinical outcomes in individuals who had the virus.
- Conducted at a post-COVID-19 clinic, the trial involved 72 post-COVID patients and 11 control participants, with follow-up assessments at 3, 6, and 12 months post-diagnosis.
- Results indicated increased median intima-media thickness (IMT) in COVID-19 patients compared to controls, changes in blood cell markers and responses based on severity of infection, but no instances of deep vein thrombosis were found.
Background: Plain language summaries (PLSs) are easy-to-understand summaries of research articles that should follow principles of plain language and health literacy. PLS author instructions from health journals help guide authors on word count/PLS length, structure and the use of jargon. However, it is unclear whether published PLSs currently adhere to author instructions.
View Article and Find Full Text PDFGP Engagement: A Proposed Model to Guide Engagement Activities in Australian Primary Health Networks.
J Prim Care Community Health
October 2024
Background: Engagement with general practice is a requirement of Australia's Primary Health Networks (PHNs). We propose a model for engagement that draws on principles of stakeholder and clinician engagement, tailored to meet the needs of PHNs and general practitioners (GPs).
Methods: A comprehensive literature review was undertaken to identify components, challenges, and approaches to optimizing clinician engagement.