Publications by authors named "S C Chime"
Article Synopsis
- Dexmedetomidine is a medication used for sedation, initially approved for adults in hospitals and now also used off-label for children during procedures like MRI.
- A study was conducted to assess the safety and effectiveness of dexmedetomidine in children aged 1 month to 17 years, examining various dosages to see how many could complete an MRI without needing extra anesthesia.
- Results showed that a higher dose of dexmedetomidine significantly increased the number of children who completed the MRI without needing additional sedation, with some mild adverse effects observed.
Ibuprofen is a member of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAIDs) with anti-inflammatory, analgesic, and antipyretic activities used to relieve a variety of pains. The objective of this study was to formulate, characterize and evaluate the in vitro and in vivo properties of ibuprofen formulated as solid lipid microspheres (SLMs) for enhanced delivery. The mixtures of Irvingia wombolu fat (IRW) and moringa oil (MO) each with Phospholipon® 90G (PL90G) at the ratio of 2:1 w/w were prepared by fusion, characterized and used to prepare SLMs.
View Article and Find Full Text PDFBackground: Proximal femoral geometry(PFG) plays a role in the biomechanics of the hip. During total hip replacement detailed efforts are made to restore this biomechanics in other to ensure patients satisfaction and implant survival. There are variations in these parameters.
View Article and Find Full Text PDFBackground: Lipid-based formulations have been confirmed to lower some side effects of drugs and can be tailor-made to offer sustained drug release of drugs with short half-life like stavudine.
Aim: This study aimed to evaluate the immunomodulatory properties of stavudine-loaded solid lipid microparticles (SLMs) using immunocompromised Wistar rats.
Methods: The SLMs were formulated by the homogenization method.
Anti-Inflammatory and Gastroprotective Properties of Aspirin - Entrapped Solid Lipid Microparticles.
Recent Pat Inflamm Allergy Drug Discov
December 2020
Background: Aspirin is a nonsteroidal anti-inflammatory drug that is very effective in the treatment of inflammation and other health conditions, however, it causes gastric irritation. Recently, researchers have developed patents (US9757529, 2019) of inhalable aspirin for rapid absorption and circumvention of gastric irritation.
Objective: The aim of this work was to formulate aspirin-loaded lipid based formulation in order to enhance oral bioavailability and inhibit gastric irritation.