Publications by authors named "S C Booth"
Background: Procarbazine-containing chemotherapy regimens are associated with cytopenias and infertility, suggesting stem-cell toxicity. When treating Hodgkin lymphoma, procarbazine in escalated-dose bleomycin-etoposide-doxorubicin-cyclophosphamide-vincristine-procarbazine-prednisolone (eBEACOPP) is increasingly replaced with dacarbazine (eBEACOPDac) to reduce toxicity. We aimed to investigate the impact of this drug substitution on the mutation burden in stem cells, patient survival, and toxicity.
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- - The case report discusses treating a child with chronic non-bacterial osteomyelitis (CNO) in the jaw, which is a rare, non-infectious condition.
- - The patient showed symptoms like facial swelling and pain, and various medical tests helped confirm the diagnosis, though the cause was unclear.
- - Successful management of CNO involves a team-based approach among different specialties, and orthodontic treatment should be customized based on individual patient needs.
Understanding why certain neurons are more sensitive to dysfunction and death caused by misfolded proteins could provide therapeutically relevant insights into neurodegenerative disorders. Here, we harnessed single-cell transcriptomics to examine live neurons isolated from prion-infected female mice, aiming to identify and characterize prion-vulnerable neuronal subsets. Our analysis revealed distinct transcriptional responses across neuronal subsets, with a consistent pathway-level depletion of synaptic gene expression in damage-vulnerable neurons.
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- Variably Protease Sensitive Prionopathy (VPSPr) is a rare, fatal human prion disease that differs from other prion diseases like Creutzfeldt-Jakob disease (CJD), particularly in the sensitivity of its prion proteins to digestion by proteinase.
- The disease is characterized by distinctive protein fragments (23, 17, and 7 kDa) that arise after digestion, especially notable in cases with the codon 129 VV genotype, where a unique 7 kDa fragment can be harder to identify with traditional methods.
- Researchers have found that using capillary electrophoresis (CE) offers a more sensitive and reproducible approach for detecting and analyzing these prion proteins, allowing for