Publications by authors named "S C Bodine"
Article Synopsis
- Endurance exercise training (ExT) leads to significant changes in lipid composition across various tissues, highlighting the need for a deeper understanding of these alterations.
- In a study involving Fischer-344 rats, it was found that both male and female rats show distinct lipid remodeling in tissues like the heart, liver, and skeletal muscle after different durations of ExT.
- Exercise resulted in lower body fat and better cardiorespiratory fitness, with important changes in types of lipids (like phospholipids and ceramides) that could help explain how exercise benefits overall health.
Per-and polyfluorinated substances (PFAS) are synthetic chemicals that are used to make fluoropolymer coatings found in many products, such as non-stick pans, clothing, cosmetics, and food packaging. These highly persistent molecules are known as "forever chemicals" since they neither degrade environmentally nor break down enzymatically within biological systems. PFAS compounds readily contaminate water sources, and as a result, certain PFAS molecules have bioaccumulated in exposed species including humans.
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- Regular physical activity is essential for overall health, but understanding how endurance exercise affects molecular signaling is still a work in progress.
- The MoTrPAC project aims to explore these molecular responses by conducting structured endurance training on Fischer 344 rats of different ages and sexes, analyzing various tissues and other biological samples.
- The study found significant improvements in muscle function and fitness markers within just a few weeks of exercise, highlighting age- and sex-related differences and providing valuable resources for future research on exercise responses.
Article Synopsis
- Seasonal variations in traits among breeding birds show phenotypic flexibility that helps them adapt to changing environmental conditions.
- The study focused on comparing muscle and body changes in migratory white-crowned sparrows and a resident subspecies, revealing that migrants prepare for migration with increased muscle and fat during spring but show different adaptations in the fall.
- Results indicated that resident birds are generally heavier with more robust leg muscles, while migrants have larger wings and hearts, demonstrating that flexible adaptations are aligned with their life history stages and energy demands.
Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consortium mapped the temporal, multi-omic changes in mitochondrial analytes across 19 tissues in male and female rats trained for 1, 2, 4, or 8 weeks.
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