Publications by authors named "S C Bergkamp"
Objectives: In childhood-onset SLE (cSLE), patients have an increased risk of premature atherosclerosis. The pathophysiological mechanisms for this premature atherosclerosis are not yet completely understood, but besides traditional risk factors, the endothelium plays a major role. The first aim of this study was to measure levels of SLE-associated markers involved in endothelial cell (EC) function and lipids in a cSLE cohort longitudinally in comparison with healthy controls (HC).
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- Juvenile idiopathic arthritis (JIA) is a chronic autoimmune condition in children that can lead to joint issues and often co-occurs with uveitis; adalimumab is a targeted treatment for both conditions.
- The study aimed to analyze the pharmacokinetics (PK) of adalimumab in JIA patients by comparing existing PK models and creating a new model specific to this demographic.
- Results from 50 JIA patients indicated that body weight, antidrug antibodies, and other factors influenced adalimumab clearance, with a recommended clearance rate established for more personalized treatment approaches.
Article Synopsis
- The study aims to validate the childhood lupus low disease activity state (cLLDAS) in children with systemic lupus erythematosus (cSLE) by comparing the time to reach adult LLDAS (aLLDAS) and identifying predictors for maintaining cLLDAS.
- A cohort of 50 cSLE patients was analyzed over a median follow-up of 3.1 years, showing that while all patients reached aLLDAS and cLLDAS at least once, 58% maintained cLLDAS for at least half of the follow-up, with significant negative predictors identified.
- The study concludes that the time to reach cLLDAS differs from aLL
Objectives: Rituximab (RTX), used for treatment in paediatric immune-mediated diseases, can lead to hypogammaglobulinaemia and thus to an increased risk of infection, but data on these adverse effects in children are scarce. We aimed to describe the pharmacodynamics of RTX by time to B cell repopulation in paediatric immune-mediated diseases and to assess whether low post-RTX immunoglobulin levels were associated with frequency and severity of infections.
Methods: Data of children with autoimmune diseases (AID), immune dysregulation (ID), haematological diseases (HD) and renal diseases (RD), including immunoglobulin levels pre-/post-RTX and occurrence of infections, who had received RTX at our centre were retrospectively collected.
Background: Nailfold video capillaroscopy (NVC) is a simple, non-invasive diagnostic tool but studies with normal values for capillary density in healthy children are rare. Ethnic background seems to play a role in capillary density; however, this is not well substantiated yet. In this work, we set out to evaluate influence of ethnic background/skin pigmentation and age on capillary density reading in healthy children.
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