IN SILICO AND IN VITRO ASSESSMENT OF ANTI-Leishmania infantum ACTIVITY OF A NOVEL CYCLOHEXYL-1,2,4-OXADIAZOLE DERIVATIVE.

Globally, an estimated 1 billion people reside in endemic areas, and over 12 million individuals are infected with leishmaniasis. Despite its prevalence, leishmaniasis continues to be a neglected disease, mainly affecting underdeveloped countries. In Brazil, the available treatments are pentavalent antimonials and Amphotericin B, which are outdated, toxic, require prolonged parenteral administration and have limited efficacy.

Effects of photobiomodulation therapy (660-nm laser) on median nerve function in Wistar rats.

This study investigates the effects of photobiomodulation (PBM) with a 660-nm laser on nerve regeneration and muscle morphometry following median nerve axonotmesis in rats. Sixteen Wistar rats were divided into a control group and laser-treated group, with the latter receiving 10 applications of PBM (660 nm; 20 mW; 10 J/cm; 0.4 J; and 20 s) over 2 weeks.

Presence of multidrug-resistant bacteria on ready-to-use laryngoscope blades and handles: a cross-sectional study.

Background: The presence of microorganisms in laryngoscopes emphasizes the risk to patient safety during orotracheal intubations.

Methods: Cross-sectional study was carried out in university hospital in the inpatient, emergency, intensive care and surgical center sectors. Microorganisms were recovered from the blades using a filter membrane and from the handles using swab.

Protective Effects of Spondias mombin L. Juice Alone or in Combination With Lactobacillus acidophilus in 5-Fluorouracil-Induced Experimental Intestinal Mucositis.

Background: Evaluate the impact of Spondias mombin L. juice (SM), alone and in combination with Lactobacillus acidophilus, in an experimental model of intestinal mucositis.

Methods: Swiss mice were orally administered with saline, SM, or SM combined with L.